Version 5.4
Homo sapiens Gene: SLAMF8
Summary
InnateDB Gene IDBG-103936.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLAMF8
Gene Name SLAM family member 8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000158714
Encoded Proteins
IDBP-103938
SLAM family member 8
IDBP-103940
SLAM family member 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18501771
The SLAM and SAP gene families control innate and adaptive immune responses
Entrez Gene
Summary This gene encodes a member of the CD2 family of cell surface proteins involved in lymphocyte activation. These proteins are characterized by Ig domains. This protein is expressed in lymphoid tissues, and studies of a similar protein in mouse suggest that it may function during B cell lineage commitment. The gene is found in a region of chromosome 1 containing many CD2 genes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:159826750-159837249
Strand Forward strand
Band q23.2
Transcripts
ENST00000289707 ENSP00000289707
ENST00000368104 ENSP00000357084
ENST00000471286
ENST00000497141
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0033860 regulation of NAD(P)H oxidase activity
GO:0035690 cellular response to drug
GO:0042742 defense response to bacterium
GO:0043549 regulation of kinase activity
GO:0045087 innate immune response (InnateDB)
GO:0090383 phagosome acidification
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000053318
View Gene Order
ENSBTAG00000016698
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.438683
RefSeq NM_020125
HUGO
OMIM
CCDS CCDS1188
HPRD 09429
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca