Version 5.4
Homo sapiens Gene: RFWD2
Summary
InnateDB Gene IDBG-104993.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RFWD2
Gene Name ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143207
Encoded Proteins
IDBP-104995
ring finger and WD repeat domain 2
IDBP-104997
ring finger and WD repeat domain 2
IDBP-104999
ring finger and WD repeat domain 2
IDBP-105001
ring finger and WD repeat domain 2
IDBP-586271
ring finger and WD repeat domain 2
IDBP-597067
ring finger and WD repeat domain 2
IDBP-595772
ring finger and WD repeat domain 2
IDBP-600187
ring finger and WD repeat domain 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:175944831-176207493
Strand Reverse strand
Band q25.2
Transcripts
ENST00000367669 ENSP00000356641
ENST00000367667 ENSP00000356639
ENST00000367666 ENSP00000356638
ENST00000308769 ENSP00000310943
ENST00000461830
ENST00000482305
ENST00000459744 ENSP00000437212
ENST00000498306 ENSP00000433810
ENST00000491600 ENSP00000437275
ENST00000474194 ENSP00000433517
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 96 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 96 [view]
Protein-Protein 95 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0016567 protein ubiquitination
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0016607 nuclear speck
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040782
View Gene Order
ENSBTAG00000031385
Not yet available
Pathways
NETPATH
REACTOME
REACT_20549
Autodegradation of the E3 ubiquitin ligase COP1 pathway
REACT_309
Stabilization of p53 pathway
REACT_1625
p53-Dependent G1 DNA Damage Response pathway
REACT_85
p53-Dependent G1/S DNA damage checkpoint pathway
REACT_115566
Cell Cycle pathway
REACT_2254
G1/S DNA Damage Checkpoints pathway
REACT_1538
Cell Cycle Checkpoints pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04115
p53 signaling pathway pathway
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
p53regulationpathway
p53 pathway
atm_pathway
ATM pathway
Cross-References
SwissProt Q8NHY2
TrEMBL B3KM72 E9PJB5 E9PKI0 E9PMW8 H0Y339 X5D7N8 X5D9B4 X5DNY7
UniProt Splice Variant
Entrez Gene 64326
UniGene Hs.523744 Hs.607534 Hs.670708
RefSeq NM_001001740 NM_001286644 NM_022457 XM_005245447 XM_005245448 XM_006711488 XM_006711489
HUGO HGNC:17440
OMIM 608067
CCDS CCDS30944 CCDS44279
HPRD
IMGT
EMBL AF508940 AF527539 AK001278 AK025789 AK314750 AL162736 AL359265 AL513329 AL590723 AY509921 BC094728 BK000438 CH471067 KJ534928 KJ534930 KJ534931 KJ535076
GenPept AAH94728 AAM34692 AAQ08989 AAS82851 AHW56568 AHW56570 AHW56571 AHW56715 BAB15239 BAG37289 BAG50884 CAH71140 CAH72425 CAH73625 CAI14643 DAA01050 EAW91000
RNA Seq Atlas 64326

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca