Version 5.4
Homo sapiens Gene: RGS13
Summary
InnateDB Gene IDBG-105448.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RGS13
Gene Name regulator of G-protein signaling 13
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000127074
Encoded Proteins
IDBP-246562
regulator of G-protein signaling 13
IDBP-592761
regulator of G-protein signaling 13
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:192636138-192660306
Strand Forward strand
Band q31.2
Transcripts
ENST00000391995 ENSP00000375853
ENST00000462955
ENST00000482095
ENST00000543215 ENSP00000442837
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043547 positive regulation of GTPase activity
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000051079
View Gene Order
ENSBTAG00000013849
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt O14921
TrEMBL A0A024R989
UniProt Splice Variant
Entrez Gene 6003
UniGene Hs.497220
RefSeq NM_144766 NM_002927
HUGO HGNC:9995
OMIM 607190
CCDS CCDS1376
HPRD 06222
IMGT
EMBL AF030107 AF493935 AL136454 AL596119 AY562947 BC016667 BC056866 BT006929 CH471067 CR536532
GenPept AAB84000 AAH16667 AAH56866 AAM12649 AAP35575 AAS66360 CAG38769 CAH71773 CAI17062 EAW91229 EAW91230
RNA Seq Atlas 6003

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca