Version 5.4
Mus musculus Gene: Rgs13
Summary
InnateDB Gene IDBG-197148.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rgs13
Gene Name regulator of G-protein signaling 13
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000051079
Encoded Proteins
IDBP-197150
regulator of G-protein signaling 13
IDBP-257061
regulator of G-protein signaling 13
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127074:
The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:144138654-144177372
Strand Reverse strand
Band F
Transcripts
ENSMUST00000052375 ENSMUSP00000058813
ENSMUST00000111941 ENSMUSP00000107572
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043547 positive regulation of GTPase activity
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000127074
View Gene Order
ENSBTAG00000013849
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
INOH website
GPCR signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt Q8K443
TrEMBL
UniProt Splice Variant
Entrez Gene 246709
UniGene Mm.38271
RefSeq XM_006529613 NM_153171
OMIM
CCDS CCDS15348
HPRD
IMGT
MGI ID MGI:2180585
MGI Symbol Rgs13
EMBL AF498319 AK043268 BC049624
GenPept AAH49624 AAM74139 BAC31511
RNA Seq Atlas 246709

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca