Version 5.4
Homo sapiens Gene: GLRX2
Summary
InnateDB Gene IDBG-105482.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GLRX2
Gene Name glutaredoxin 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000023572
Encoded Proteins
IDBP-105484
glutaredoxin 2
IDBP-105486
glutaredoxin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the glutaredoxin family of proteins, which maintain cellular thiol homeostasis. These proteins are thiol-disulfide oxidoreductases that use a glutathione-binding site and one or two active cysteines in their active site. This gene undergoes alternative splicing to produce multiple isoforms, one of which is ubiquitously expressed and localizes to mitochondria, where it functions in mitochondrial redox homeostasis and is important for the protection against and recovery from oxidative stress. Other isoforms, which have more restrictive expression patterns, show cytosolic and nuclear localization, and are thought to function in cellular differentiation and transformation, possibly with a role in tumor progression. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:193096468-193106114
Strand Reverse strand
Band q31.2
Transcripts
ENST00000367440 ENSP00000356410
ENST00000367439 ENSP00000356409
ENST00000472197
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003756 protein disulfide isomerase activity
GO:0008794 arsenate reductase (glutaredoxin) activity
GO:0009055 electron carrier activity
GO:0015035 protein disulfide oxidoreductase activity
GO:0015038 glutathione disulfide oxidoreductase activity
GO:0046872 metal ion binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006457 protein folding
GO:0006749 glutathione metabolic process
GO:0006915 apoptotic process
GO:0009266 response to temperature stimulus
GO:0009966 regulation of signal transduction
GO:0010033 response to organic substance
GO:0030154 cell differentiation
GO:0042262 DNA protection
GO:0042542 response to hydrogen peroxide
GO:0045454 cell redox homeostasis
GO:0051775 response to redox state
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018196
View Gene Order
ENSBTAG00000015972
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001243399 NM_016066 NM_197962 XM_005245231
HUGO
OMIM
CCDS CCDS1380 CCDS1381
HPRD 12112
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca