Version 5.4
| Mus musculus Gene: Ptpn7 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-194348.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Ptpn7 | ||||||||
| Gene Name | protein tyrosine phosphatase, non-receptor type 7 | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Gene | ENSMUSG00000031506 | ||||||||
| Encoded Proteins |
protein tyrosine phosphatase, non-receptor type 7
protein tyrosine phosphatase, non-receptor type 7
protein tyrosine phosphatase, non-receptor type 7
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143851:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2010] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 1:135132700-135145317 | ||||||||
| Strand | Forward strand | ||||||||
| Band | E4 | ||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||
| NETPATH | |||||||||
| REACTOME | |||||||||
| KEGG |
MAPK signaling pathway pathway
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| INOH | |||||||||
| PID NCI | |||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH |
TSLP pathway
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| REACTOME | |||||||||
| KEGG |
MAPK signaling pathway pathway
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| INOH | |||||||||
| PID NCI |
Downstream signaling in naïve CD8+ T cells
Ras signaling in the CD4+ TCR pathway
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| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | Q8BX26 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 320139 | ||||||||
| UniGene | |||||||||
| RefSeq | NM_177081 XM_006529696 XM_006529697 XM_006529698 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS15315 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| MGI ID | MGI:2156893 | ||||||||
| MGI Symbol | Ptpn7 | ||||||||
| EMBL | AK049175 AK083305 BC098475 | ||||||||
| GenPept | AAH98475 BAC33587 BAC38856 | ||||||||
| RNA Seq Atlas | 320139 | ||||||||