InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IL19

Summary

InnateDB Gene

IDBG-106273.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL19

Gene Name

interleukin 19

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000142224

Encoded Proteins

IDBP-106275

interleukin 19

IDBP-106277

interleukin 19

IDBP-809027

interleukin 19

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21157117

IL19 cytokine is a member of the interleukin 10 (IL10) family that includes IL20, IL22, IL24, and IL26 and has been shown to negatively regulate the innate immune system.

InnateDB Annotation from Orthologs

Summary

PMID 24677051

[Mus musculus] Astrocytes produce IL19 and express IL19 receptors (Il20ra and Il20rb) in response to bacterial pathogens. IL19 can significantly attenuate bacterially induced inflammatory astrocyte responses

Entrez Gene

Summary

The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:206798870-206842981

Strand

Forward strand

Band

q32.1

Transcripts

ENST00000270218	ENSP00000270218
ENST00000340758	ENSP00000343000
ENST00000476097
ENST00000620365	ENSP00000482668

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity

Biological Process

GO:0006915	apoptotic process
GO:0006955	immune response
GO:0007165	signal transduction
GO:0042226	interleukin-6 biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0072593	reactive oxygen species metabolic process
GO:2001235	positive regulation of apoptotic signaling pathway
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000016524

View Gene Order

ENSBTAG00000006692

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04630

Jak-STAT signaling pathway pathway

INOH

PID NCI

il23pathway

IL23-mediated signaling events

Cross-References

SwissProt

Q9UHD0

TrEMBL

UniProt Splice Variant

Entrez Gene

29949

UniGene

Hs.661017

RefSeq

NM_013371 NM_153758

HUGO

HGNC:5990

OMIM

605687

CCDS

CCDS1468 CCDS1469

HPRD

IMGT

EMBL

AF192498 AF276915 AF390905 AF453946 AL049615 AL513315 AY040367

GenPept

AAF06663 AAG16755 AAK64498 AAK91776 AAN40906 CAB72342 CAH71814

RNA Seq Atlas

29949