InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Il19

Summary

InnateDB Gene

IDBG-190663.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il19

Gene Name

interleukin 19

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000016524

Encoded Proteins

IDBP-190665

interleukin 19

IDBP-255951

interleukin 19

IDBP-789528

interleukin 19

IDBP-789529

interleukin 19

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 24677051

Astrocytes produce IL19 and express IL19 receptors (Il20ra and Il20rb) in response to bacterial pathogens. IL19 can significantly attenuate bacterially induced inflammatory astrocyte responses

InnateDB Annotation from Orthologs

Summary

PMID 21157117

[Homo sapiens] IL19 cytokine is a member of the interleukin 10 (IL10) family that includes IL20, IL22, IL24, and IL26 and has been shown to negatively regulate the innate immune system.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142224:
The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:130932656-130940115

Strand

Reverse strand

Band

Transcripts

ENSMUST00000016668	ENSMUSP00000016668
ENSMUST00000112465	ENSMUSP00000108084
ENSMUST00000187410	ENSMUSP00000139406
ENSMUST00000187916	ENSMUSP00000141175

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity

Biological Process

GO:0006915	apoptotic process
GO:0042226	interleukin-6 biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0072593	reactive oxygen species metabolic process
GO:2001235	positive regulation of apoptotic signaling pathway
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005615

extracellular space

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000142224

View Gene Order

ENSBTAG00000006692

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04060

Cytokine-cytokine receptor interaction pathway

mmu04630

Jak-STAT signaling pathway pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04630

Jak-STAT signaling pathway pathway

INOH

PID NCI

il23pathway

IL23-mediated signaling events

Cross-References

SwissProt

TrEMBL

Q14BK1

UniProt Splice Variant

Entrez Gene

329244

UniGene

RefSeq

XM_006529705 XM_006529706 NM_001009940

OMIM

CCDS

CCDS15264

HPRD

IMGT

MGI ID

MGI:1890472

MGI Symbol

Il19

EMBL

AF453945 BC115793 CH466520

GenPept

AAI15794 AAN40905 EDL39724

RNA Seq Atlas

329244