Version 5.4
Homo sapiens Gene: PFKFB2
Summary
InnateDB Gene IDBG-106316.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PFKFB2
Gene Name 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
Synonyms PFK-2/FBPase-2
Species Homo sapiens
Ensembl Gene ENSG00000123836
Encoded Proteins
IDBP-106318
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
IDBP-106320
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
IDBP-389974
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
IDBP-811104
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
IDBP-584470
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
IDBP-811056
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:207034366-207081024
Strand Forward strand
Band q32.1
Transcripts
ENST00000367080 ENSP00000356047
ENST00000367079 ENSP00000356046
ENST00000411990 ENSP00000408717
ENST00000464777 ENSP00000484769
ENST00000468857
ENST00000473310
ENST00000483688
ENST00000545806 ENSP00000439420
ENST00000615360
ENST00000618513 ENSP00000484988
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003873 6-phosphofructo-2-kinase activity
GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019900 kinase binding
GO:0019901 protein kinase binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006000 fructose metabolic process
GO:0006003 fructose 2,6-bisphosphate metabolic process
GO:0006006 glucose metabolic process
GO:0006007 glucose catabolic process
GO:0006089 lactate metabolic process
GO:0006090 pyruvate metabolic process
GO:0006096 glycolytic process
GO:0009749 response to glucose
GO:0016311 dephosphorylation
GO:0032024 positive regulation of insulin secretion
GO:0033133 positive regulation of glucokinase activity
GO:0044281 small molecule metabolic process
GO:0046835 carbohydrate phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026409
View Gene Order
ENSBTAG00000002126
Not yet available
Pathways
NETPATH
REACTOME
REACT_1383
Glycolysis pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_111217
Metabolism pathway
REACT_116125
Disease pathway
REACT_723
Glucose metabolism pathway
REACT_200833
Glycogen storage diseases pathway
KEGG
hsa00051
Fructose and mannose metabolism pathway
INOH
INOH website
Fructose Mannose metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.282702 Hs.597325 Hs.609353
RefSeq NM_001018053 NM_006212 XM_005273162 XM_006711381 XM_006711382
HUGO
OMIM
CCDS CCDS31003 CCDS31004
HPRD 01383
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca