InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PFKFB2

Summary

InnateDB Gene

IDBG-629238.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PFKFB2

Gene Name

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 6-phosphofructo-2-kinase Fructose-2,6-bisphosphatase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002126

Encoded Proteins

IDBP-680639

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 26-phosphofructo-2-kinaseFructose-2,6-bisphosphatase

IDBP-680641

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 26-phosphofructo-2-kinaseFructose-2,6-bisphosphatase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123836:
The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:4725743-4752781

Strand

Forward strand

Band

Transcripts

ENSBTAT00000002753	ENSBTAP00000002753
ENSBTAT00000053481	ENSBTAP00000050645

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003824	catalytic activity
GO:0003873	6-phosphofructo-2-kinase activity
GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016787	hydrolase activity
GO:0019901	protein kinase binding

Biological Process

GO:0006000	fructose metabolic process
GO:0006003	fructose 2,6-bisphosphate metabolic process
GO:0006096	glycolytic process
GO:0008152	metabolic process
GO:0016310	phosphorylation
GO:0016311	dephosphorylation
GO:0046835	carbohydrate phosphorylation