InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Bpnt1

Summary

InnateDB Gene

IDBG-207995.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bpnt1

Gene Name

bisphosphate 3'-nucleotidase 1

Synonyms

BPntase

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026617

Encoded Proteins

IDBP-207997

bisphosphate 3'-nucleotidase 1

IDBP-259111

bisphosphate 3'-nucleotidase 1

IDBP-541527

bisphosphate 3'-nucleotidase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162813:
BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008]
BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92%% identical to mouse BPntase. BPntase\'s physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:185332149-185357777

Strand

Forward strand

Band

Transcripts

ENSMUST00000027916	ENSMUSP00000027916
ENSMUST00000110965	ENSMUSP00000106590
ENSMUST00000151769	ENSMUSP00000117122
ENSMUST00000137757

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004441	inositol-1,4-bisphosphate 1-phosphatase activity
GO:0008441	3'(2'),5'-bisphosphate nucleotidase activity