Version 5.4
Homo sapiens Gene: PIWIL2
Summary
InnateDB Gene IDBG-10698.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIWIL2
Gene Name piwi-like 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000197181
Encoded Proteins
IDBP-10702
piwi-like 2 (Drosophila)
IDBP-362954
piwi-like 2 (Drosophila)
IDBP-478938
piwi-like 2 (Drosophila)
IDBP-807605
piwi-like RNA-mediated gene silencing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary PIWIL2 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:22275297-22357563
Strand Forward strand
Band p21.3
Transcripts
ENST00000356766 ENSP00000349208
ENST00000454009 ENSP00000406956
ENST00000521356 ENSP00000428267
ENST00000519884
ENST00000611073 ENSP00000478103
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0034584 piRNA binding
Biological Process
GO:0000966 RNA 5'-end processing
GO:0007126 meiotic nuclear division
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0030718 germ-line stem cell maintenance
GO:0031047 gene silencing by RNA
GO:0034587 piRNA metabolic process
GO:0043046 DNA methylation involved in gamete generation
GO:0045727 positive regulation of translation
GO:0048477 oogenesis
GO:0060903 positive regulation of meiosis I
Cellular Component
GO:0005737 cytoplasm
GO:0005844 polysome
GO:0033391 chromatoid body
GO:0043186 P granule
GO:0071546 pi-body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033644
View Gene Order
ENSBTAG00000015835
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04320
Dorso-ventral axis formation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.274150 Hs.613602
RefSeq NM_001135721 NM_018068 XM_005273550 XM_005273551
HUGO
OMIM
CCDS CCDS6029
HPRD 11434
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca