Version 5.4
Homo sapiens Gene: TBCE
Summary
InnateDB Gene IDBG-107548.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBCE
Gene Name tubulin folding cofactor E
Synonyms HRD; KCS; KCS1; pac2
Species Homo sapiens
Ensembl Gene ENSG00000116957
Encoded Proteins
IDBP-107550
tubulin folding cofactor E
IDBP-295746
tubulin folding cofactor E
IDBP-589986
tubulin folding cofactor E
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:235367360-235448968
Strand Forward strand
Band q42.3
Transcripts
ENST00000366601 ENSP00000355560
ENST00000406207 ENSP00000384571
ENST00000482230
ENST00000472011
ENST00000461651
ENST00000465463
ENST00000543662 ENSP00000439170
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003735 structural constituent of ribosome
GO:0051087 chaperone binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0006412 translation
GO:0006457 protein folding
GO:0007023 post-chaperonin tubulin folding pathway
GO:0007409 axonogenesis
GO:0008344 adult locomotory behavior
GO:0009791 post-embryonic development
GO:0014889 muscle atrophy
GO:0044267 cellular protein metabolic process
GO:0048589 developmental growth
GO:0048936 peripheral nervous system neuron axonogenesis
GO:0051084 'de novo' posttranslational protein folding
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0005874 microtubule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039233
View Gene Order
ENSBTAG00000013735
Not yet available
Pathways
NETPATH
REACTOME
REACT_16967
Post-chaperonin tubulin folding pathway pathway
REACT_16952
Protein folding pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.498143
RefSeq NM_001079515 NM_001287801 NM_001287802 NM_003193
HUGO
OMIM
CCDS CCDS1605 CCDS73052
HPRD 05381
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca