Version 5.4
Homo sapiens Gene: CEP170
Summary
InnateDB Gene IDBG-107733.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CEP170
Gene Name centrosomal protein 170kDa
Synonyms FAM68A; KAB; KIAA0470
Species Homo sapiens
Ensembl Gene ENSG00000143702
Encoded Proteins
IDBP-35432
centrosomal protein 170kDa
IDBP-107735
centrosomal protein 170kDa
IDBP-107737
centrosomal protein 170kDa
IDBP-107739
centrosomal protein 170kDa
IDBP-390198
centrosomal protein 170kDa
IDBP-484837
centrosomal protein 170kDa
IDBP-483249
centrosomal protein 170kDa
IDBP-474879
centrosomal protein 170kDa
IDBP-481691
centrosomal protein 170kDa
IDBP-481315
centrosomal protein 170kDa
IDBP-483320
centrosomal protein 170kDa
IDBP-479671
centrosomal protein 170kDa
IDBP-483362
centrosomal protein 170kDa
IDBP-477384
centrosomal protein 170kDa
IDBP-808507
centrosomal protein 170kDa
IDBP-808508
centrosomal protein 170kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:243124428-243255406
Strand Reverse strand
Band q43
Transcripts
ENST00000336415 ENSP00000338161
ENST00000366544 ENSP00000355502
ENST00000366543 ENSP00000355501
ENST00000366542 ENSP00000355500
ENST00000439296
ENST00000451408
ENST00000413359 ENSP00000394002
ENST00000468254
ENST00000481987 ENSP00000427842
ENST00000466495
ENST00000476661
ENST00000490813 ENSP00000430142
ENST00000469646
ENST00000464936 ENSP00000427843
ENST00000468697
ENST00000492145 ENSP00000430112
ENST00000518289
ENST00000522895 ENSP00000428996
ENST00000461671 ENSP00000428777
ENST00000521911
ENST00000522191 ENSP00000427944
ENST00000523424 ENSP00000428183
ENST00000522522
ENST00000522995 ENSP00000428400
ENST00000523581
ENST00000619357 ENSP00000478367
ENST00000621831 ENSP00000484359
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005814 centriole
GO:0005819 spindle
GO:0005874 microtubule
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000057335
View Gene Order
ENSBTAG00000007566
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.533635 Hs.721765 Hs.722770 Hs.733787
RefSeq NM_001042404 NM_001042405 NM_014812 XM_006711843 XM_006711849 XM_006711851 XM_006711852 XM_006724974 XM_006724981 XM_006724983 XM_006724984
HUGO
OMIM
CCDS CCDS44337 CCDS44338 CCDS44339
HPRD 17172
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca