Version 5.4
Homo sapiens Gene: TUBA8
Summary
InnateDB Gene IDBG-1124.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TUBA8
Gene Name tubulin, alpha 8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000183785
Encoded Proteins
IDBP-1128
tubulin, alpha 8
IDBP-1130
tubulin, alpha 8
IDBP-361236
tubulin, alpha 8
IDBP-361249
tubulin, alpha 8
IDBP-810161
tubulin, alpha 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the alpha tubulin protein family. Alpha tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Mutations in this gene are associated with polymicrogyria and optic nerve hypoplasia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:18110331-18146554
Strand Forward strand
Band q11.21
Transcripts
ENST00000330423 ENSP00000333326
ENST00000316027 ENSP00000318575
ENST00000426208 ENSP00000407624
ENST00000416740 ENSP00000412646
ENST00000608634 ENSP00000477306
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 17 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007017 microtubule-based process
GO:0051258 protein polymerization
Cellular Component
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030137
View Gene Order
ENSBTAG00000018530
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa05130
Pathogenic Escherichia coli infection pathway
hsa04540
Gap junction pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL C9K0S6
UniProt Splice Variant
Entrez Gene 51807
UniGene Hs.137400
RefSeq NM_001193414 NM_018943
HUGO HGNC:12410
OMIM 605742
CCDS CCDS13751 CCDS54495
HPRD 05763
IMGT
EMBL AC008079 AC016027
GenPept
RNA Seq Atlas 51807

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca