Version 5.4
Homo sapiens Gene: RHOBTB2
Summary
InnateDB Gene IDBG-11308.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RHOBTB2
Gene Name Rho-related BTB domain containing 2
Synonyms DBC2
Species Homo sapiens
Ensembl Gene ENSG00000008853
Encoded Proteins
IDBP-11312
Rho-related BTB domain containing 2
IDBP-482438
Rho-related BTB domain containing 2
IDBP-481694
Rho-related BTB domain containing 2
IDBP-483159
Rho-related BTB domain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:22987417-23020199
Strand Forward strand
Band p21.3
Transcripts
ENST00000251822 ENSP00000251822
ENST00000519685 ENSP00000427926
ENST00000524077 ENSP00000430785
ENST00000518534
ENST00000522948 ENSP00000429141
ENST00000517528
ENST00000523918
ENST00000519210
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022075
View Gene Order
ENSBTAG00000031916
Not yet available
Pathways
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt Q9BYZ6
TrEMBL E5RI44
UniProt Splice Variant
Entrez Gene 23221
UniGene Hs.372688
RefSeq NM_001160036 XM_006716315 NM_001160037 NM_015178
HUGO HGNC:18756
OMIM 607352
CCDS CCDS55210 CCDS55211 CCDS6034
HPRD 06300
IMGT
EMBL AB018260 AC107959 AF315385 AK292863 AY009093 BC034917 CH471080
GenPept AAG61157 AAH34917 AAK07562 BAA34437 BAF85552 EAW63644 EAW63646
RNA Seq Atlas 23221

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca