Version 5.4
Homo sapiens Gene: BMPER
Summary
InnateDB Gene IDBG-11994.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BMPER
Gene Name BMP binding endothelial regulator
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000164619
Encoded Proteins
IDBP-11996
BMP binding endothelial regulator
IDBP-371772
BMP binding endothelial regulator
IDBP-371779
BMP binding endothelial regulator
IDBP-371781
BMP binding endothelial regulator
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. It has been shown to inhibit BMP2- and BMP4-dependent osteoblast differentiation and BMP-dependent differentiation of the chondrogenic cells. Mutations in this gene are associated with a lethal skeletal disorder, diaphanospondylodysostosis. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:33904911-34155872
Strand Forward strand
Band p14.3
Transcripts
ENST00000297161 ENSP00000297161
ENST00000448280 ENSP00000398835
ENST00000436222 ENSP00000399843
ENST00000444773 ENSP00000409998
ENST00000496609
ENST00000494786
ENST00000476525
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001657 ureteric bud development
GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0010594 regulation of endothelial cell migration
GO:0030514 negative regulation of BMP signaling pathway
GO:0042118 endothelial cell activation
GO:0048839 inner ear development
GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031963
View Gene Order
ENSBTAG00000010866
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.660998
RefSeq NM_133468
HUGO
OMIM
CCDS CCDS5442
HPRD 16368
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca