InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CDC34

Summary

InnateDB Gene

IDBG-12464.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDC34

Gene Name

cell division cycle 34 homolog (S. cerevisiae)

Synonyms

E2-CDC34; UBC3; UBCH3; UBE2R1

Species

Homo sapiens

Ensembl Gene

ENSG00000099804

Encoded Proteins

IDBP-12466

cell division cycle 34 homolog (S. cerevisiae)

IDBP-812190

cell division cycle 34

IDBP-812192

cell division cycle 34

IDBP-812193

cell division cycle 34

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:531712-542092

Strand

Forward strand

Band

p13.3

Transcripts

ENST00000215574	ENSP00000215574
ENST00000586788
ENST00000586283	ENSP00000475282
ENST00000593036
ENST00000607527	ENSP00000476107
ENST00000606065	ENSP00000475610
ENST00000606400

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	70 [view]
Protein-Protein	69 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000209	protein polyubiquitination
GO:0006270	DNA replication initiation
GO:0006464	cellular protein modification process
GO:0008152	metabolic process
GO:0016567	protein ubiquitination
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043525	positive regulation of neuron apoptotic process
GO:0043951	negative regulation of cAMP-mediated signaling
GO:0070848	response to growth factor
GO:0070936	protein K48-linked ubiquitination
GO:0090261	positive regulation of inclusion body assembly

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020307

View Gene Order

ENSBTAG00000002098

Not yet available

Pathways

NETPATH

NetPath_9

TNFalpha pathway

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

INOH

PID NCI

Cross-References

SwissProt

P49427

TrEMBL

A0A024R1Z1 U3KQ77 U3KQP9

UniProt Splice Variant

Entrez Gene

997

UniGene

RefSeq

NM_004359 XM_006722952

HUGO

HGNC:1734

OMIM

116948

CCDS

CCDS12030

HPRD

IMGT

EMBL

AC011531 AC011556 AK291554 AY650399 BC009850 BC018143 BC023979 BT006659 CH471242 L22005

GenPept

AAC37534 AAH09850 AAH18143 AAH23979 AAP35305 AAT46688 BAF84243 EAW61190 EAW61191

RNA Seq Atlas

997