InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cdc34

Summary

InnateDB Gene

IDBG-170431.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdc34

Gene Name

cell division cycle 34

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020307

Encoded Proteins

IDBP-170433

cell division cycle 34 homolog (S. cerevisiae)

IDBP-621270

cell division cycle 34 homolog (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099804:
The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:79682195-79688394

Strand

Forward strand

Band

Transcripts

ENSMUST00000020550	ENSMUSP00000020550
ENSMUST00000166603	ENSMUSP00000128806

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	49 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity

Biological Process

GO:0000209	protein polyubiquitination
GO:0006513	protein monoubiquitination
GO:0007049	cell cycle
GO:0016567	protein ubiquitination
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043525	positive regulation of neuron apoptotic process
GO:0043951	negative regulation of cAMP-mediated signaling
GO:0070848	response to growth factor
GO:0070936	protein K48-linked ubiquitination
GO:0090261	positive regulation of inclusion body assembly

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000099804

View Gene Order

ENSBTAG00000002098

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04120

Ubiquitin mediated proteolysis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_9

TNFalpha pathway

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_177613 XM_006513480 XM_006513481 XM_006513483

OMIM

CCDS

CCDS23983

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas