InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RBPJ

Summary

InnateDB Gene

IDBG-12527.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RBPJ

Gene Name

recombination signal binding protein for immunoglobulin kappa J region

Synonyms

AOS3; CBF1; csl; IGKJRB; IGKJRB1; KBF2; RBP-J; RBPJK; RBPSUH; SUH

Species

Homo sapiens

Ensembl Gene

ENSG00000168214

Encoded Proteins

IDBP-12529

recombination signal binding protein for immunoglobulin kappa J region

IDBP-12531

recombination signal binding protein for immunoglobulin kappa J region

IDBP-12533

recombination signal binding protein for immunoglobulin kappa J region

IDBP-12535

recombination signal binding protein for immunoglobulin kappa J region

IDBP-12537

recombination signal binding protein for immunoglobulin kappa J region

IDBP-12539

recombination signal binding protein for immunoglobulin kappa J region

IDBP-476090

recombination signal binding protein for immunoglobulin kappa J region

IDBP-482599

recombination signal binding protein for immunoglobulin kappa J region

IDBP-479457

recombination signal binding protein for immunoglobulin kappa J region

IDBP-474341

recombination signal binding protein for immunoglobulin kappa J region

IDBP-475739

recombination signal binding protein for immunoglobulin kappa J region

IDBP-476675

recombination signal binding protein for immunoglobulin kappa J region

IDBP-481996

recombination signal binding protein for immunoglobulin kappa J region

IDBP-481205

recombination signal binding protein for immunoglobulin kappa J region

IDBP-474321

recombination signal binding protein for immunoglobulin kappa J region

IDBP-481725

recombination signal binding protein for immunoglobulin kappa J region

IDBP-482834

recombination signal binding protein for immunoglobulin kappa J region

IDBP-474692

recombination signal binding protein for immunoglobulin kappa J region

IDBP-474557

recombination signal binding protein for immunoglobulin kappa J region

IDBP-479902

recombination signal binding protein for immunoglobulin kappa J region

IDBP-483091

recombination signal binding protein for immunoglobulin kappa J region

IDBP-481220

recombination signal binding protein for immunoglobulin kappa J region

IDBP-476208

recombination signal binding protein for immunoglobulin kappa J region

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Also, this protein can bind specifically to the recombination signal sequence of immunglobulin kappa type J segments. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2011]
The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:26163455-26435131

Strand

Forward strand

Band

p15.2

Transcripts

ENST00000348160	ENSP00000339699
ENST00000342295	ENSP00000345206
ENST00000345843	ENSP00000305815
ENST00000361572	ENSP00000354528
ENST00000342320	ENSP00000340124
ENST00000355476	ENSP00000347659
ENST00000512351	ENSP00000424789
ENST00000510778	ENSP00000427170
ENST00000506956	ENSP00000425750
ENST00000512671	ENSP00000423644
ENST00000514380
ENST00000514807	ENSP00000424989
ENST00000509158	ENSP00000424804
ENST00000513182	ENSP00000427344
ENST00000511401
ENST00000515023
ENST00000505958	ENSP00000426872
ENST00000507561	ENSP00000423907
ENST00000514730	ENSP00000425061
ENST00000507574	ENSP00000422617
ENST00000514675	ENSP00000423575
ENST00000515573	ENSP00000423406
ENST00000511546	ENSP00000422838
ENST00000504907	ENSP00000423703
ENST00000514656
ENST00000511451
ENST00000504938	ENSP00000424459
ENST00000506903
ENST00000510725
ENST00000504423	ENSP00000421804
ENST00000505727

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	66 [view]
Protein-Protein	58 [view]
Protein-DNA	7 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000150	recombinase activity
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000982	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001525	angiogenesis
GO:0001837	epithelial to mesenchymal transition
GO:0001974	blood vessel remodeling
GO:0002437	inflammatory response to antigenic stimulus
GO:0003139	secondary heart field specification
GO:0003151	outflow tract morphogenesis
GO:0003157	endocardium development
GO:0003160	endocardium morphogenesis
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003214	cardiac left ventricle morphogenesis
GO:0003222	ventricular trabecula myocardium morphogenesis
GO:0003256	regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0006310	DNA recombination
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006959	humoral immune response
GO:0007219	Notch signaling pathway
GO:0007221	positive regulation of transcription of Notch receptor target
GO:0007507	heart development
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009912	auditory receptor cell fate commitment
GO:0009957	epidermal cell fate specification
GO:0010467	gene expression
GO:0010468	regulation of gene expression
GO:0010628	positive regulation of gene expression
GO:0021983	pituitary gland development
GO:0030097	hemopoiesis
GO:0030182	neuron differentiation
GO:0030183	B cell differentiation
GO:0030216	keratinocyte differentiation
GO:0030279	negative regulation of ossification
GO:0030513	positive regulation of BMP signaling pathway
GO:0035019	somatic stem cell maintenance
GO:0035912	dorsal aorta morphogenesis
GO:0036302	atrioventricular canal development
GO:0042742	defense response to bacterium
GO:0045165	cell fate commitment
GO:0045596	negative regulation of cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048505	regulation of timing of cell differentiation
GO:0048733	sebaceous gland development
GO:0048820	hair follicle maturation
GO:0060045	positive regulation of cardiac muscle cell proliferation
GO:0060486	Clara cell differentiation
GO:0060716	labyrinthine layer blood vessel development
GO:0060844	arterial endothelial cell fate commitment
GO:0061314	Notch signaling involved in heart development
GO:0072554	blood vessel lumenization
GO:0072602	interleukin-4 secretion
GO:0097101	blood vessel endothelial cell fate specification
GO:1901186	positive regulation of ERBB signaling pathway
GO:1901189	positive regulation of ephrin receptor signaling pathway
GO:1901297	positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
GO:2000138	positive regulation of cell proliferation involved in heart morphogenesis

Cellular Component

GO:0002193	MAML1-RBP-Jkappa- ICN1 complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005730	nucleolus
GO:0005737	cytoplasm