InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CLIC1

Summary

InnateDB Gene

IDBG-125351.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLIC1

Gene Name

chloride intracellular channel 1

Synonyms

G6; NCC27

Species

Homo sapiens

Ensembl Gene

ENSG00000213719

Encoded Proteins

IDBP-807149

chloride intracellular channel 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:31730581-31739763

Strand

Reverse strand

Band

p21.33

Transcripts

ENST00000616760

ENSP00000479808

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	36 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005247	voltage-gated chloride channel activity
GO:0005254	chloride channel activity
GO:0005515	protein binding

Biological Process

GO:0006821	chloride transport
GO:0007165	signal transduction
GO:0034765	regulation of ion transmembrane transport
GO:0044070	regulation of anion transport
GO:0045669	positive regulation of osteoblast differentiation
GO:0051881	regulation of mitochondrial membrane potential
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0005903	brush border
GO:0016020	membrane
GO:0031965	nuclear membrane
GO:0034707	chloride channel complex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000007041

View Gene Order

ENSBTAG00000013533

Not yet available

Cross-References

SwissProt

TrEMBL

Q5SRT3

UniProt Splice Variant

Entrez Gene

1192

UniGene

RefSeq

NM_001287594 NM_001287593 NM_001288

HUGO

HGNC:2062

OMIM

602872

CCDS

CCDS4719

HPRD

IMGT

EMBL

AF034607 AF109197 AF129756 AJ012008 AK314014 AL662899 BA000025 BC064527 BC095469 CH471081 CR542071 U93205 X87689

GenPept

AAC25675 AAD18073 AAD20437 AAD26137 AAH64527 AAH95469 BAB63376 BAG36725 CAA61020 CAB46078 CAG46868 CAI18417 EAX03503 EAX03504

RNA Seq Atlas

1192