Version 5.4
Mus musculus Gene: Fkbp1b
Summary
InnateDB Gene IDBG-128053.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fkbp1b
Gene Name FK506 binding protein 1b
Synonyms 12.6kDa; AW494148; calstabin2; FKBP12.6
Species Mus musculus
Ensembl Gene ENSMUSG00000020635
Encoded Proteins
IDBP-128055
FK506 binding protein 1b
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119782:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:4833175-4841595
Strand Reverse strand
Band A1.1
Transcripts
ENSMUST00000020964 ENSMUSP00000020964
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0005528 FK506 binding
GO:0019855 calcium channel inhibitor activity
GO:0030551 cyclic nucleotide binding
GO:0044325 ion channel binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0002027 regulation of heart rate
GO:0006457 protein folding
GO:0006939 smooth muscle contraction
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0009749 response to glucose
GO:0010033 response to organic substance
GO:0010459 negative regulation of heart rate
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0019227 neuronal action potential propagation
GO:0030073 insulin secretion
GO:0032513 negative regulation of protein phosphatase type 2B activity
GO:0033197 response to vitamin E
GO:0042098 T cell proliferation
GO:0042542 response to hydrogen peroxide
GO:0048680 positive regulation of axon regeneration
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051280 negative regulation of release of sequestered calcium ion into cytosol
GO:0051284 positive regulation of sequestering of calcium ion
GO:0051480 cytosolic calcium ion homeostasis
GO:0051775 response to redox state
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0030018 Z disc
GO:0033017 sarcoplasmic reticulum membrane
GO:0034704 calcium channel complex
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000119782
View Gene Order
ENSBTAG00000003409
Not yet available
Pathways
NETPATH
REACTOME
REACT_196640
Stimuli-sensing channels pathway
REACT_262350
Ion channel transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
REACT_223895
Ion channel transport pathway
REACT_223103
Transmembrane transport of small molecules pathway
REACT_213748
Stimuli-sensing channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9Z2I2
TrEMBL A9E3L2
UniProt Splice Variant
Entrez Gene 14226
UniGene Mm.397053
RefSeq NM_016863
OMIM
CCDS CCDS25792
HPRD
IMGT
MGI ID MGI:1336205
MGI Symbol Fkbp1b
EMBL AB285016 AB285017 AF060872 AK005201 BC061121 CH466623
GenPept AAC64923 AAH61121 BAB23879 BAF93934 BAF93935 EDL01354
RNA Seq Atlas 14226

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca