Version 5.4
Mus musculus Gene: Tcirg1
Summary
InnateDB Gene IDBG-128443.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tcirg1
Gene Name T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3
Synonyms ATP6a3; Atp6i; ATP6N1C; oc; OC-116; OPTB1; Stv1; TIRC7; Vph1
Species Mus musculus
Ensembl Gene ENSMUSG00000001750
Encoded Proteins
IDBP-128445
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3
IDBP-540830
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3
IDBP-537928
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3
IDBP-540160
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3
IDBP-541037
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3
IDBP-534074
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110719:
Through alternate splicing, this gene encodes two proteins with similarity to subunits of the vacuolar ATPase (V-ATPase) but the encoded proteins seem to have different functions. V-ATPase is a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Mutations in this gene are associated with infantile malignant osteopetrosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:3896050-3907133
Strand Reverse strand
Band A
Transcripts
ENSMUST00000001801 ENSMUSP00000001801
ENSMUST00000126070 ENSMUSP00000120531
ENSMUST00000145791 ENSMUSP00000122474
ENSMUST00000135070 ENSMUSP00000121241
ENSMUST00000131327
ENSMUST00000122885 ENSMUSP00000114768
ENSMUST00000162688
ENSMUST00000134698
ENSMUST00000126643
ENSMUST00000132164 ENSMUSP00000120968
ENSMUST00000159824
ENSMUST00000125792
ENSMUST00000127308
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015078 hydrogen ion transmembrane transporter activity
Biological Process
GO:0015991 ATP hydrolysis coupled proton transport
Cellular Component
GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain
GO:0005739 mitochondrion
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0016324 apical plasma membrane
GO:0033179 proton-transporting V-type ATPase, V0 domain
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000110719
View Gene Order
ENSBTAG00000000292
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00190
Oxidative phosphorylation pathway
mmu04142
Lysosome pathway
mmu04145
Phagosome pathway
mmu04966
Collecting duct acid secretion pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25283
Transferrin endocytosis and recycling pathway
REACT_25060
Iron uptake and transport pathway
REACT_1109
Insulin receptor recycling pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_121256
Phagosomal maturation (early endosomal stage) pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_111102
Signal Transduction pathway
REACT_121237
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
REACT_116125
Disease pathway
KEGG
hsa05110
Vibrio cholerae infection pathway
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa00190
Oxidative phosphorylation pathway
hsa04142
Lysosome pathway
hsa04966
Collecting duct acid secretion pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F6ZFB8 Q9JHF5
UniProt Splice Variant
Entrez Gene 27060
UniGene Mm.271689
RefSeq NM_016921 NM_001136091 NM_001167784
OMIM
CCDS CCDS29401
HPRD
IMGT
MGI ID MGI:1350931
MGI Symbol Tcirg1
EMBL AB022322 AC133523 AF188702 CH466612
GenPept AAF37193 BAA93006 EDL32965 EDL32968
RNA Seq Atlas 27060

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca