Version 5.4
Homo sapiens Gene: TCIRG1
Summary
InnateDB Gene IDBG-61185.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TCIRG1
Gene Name T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
Synonyms a3; Atp6i; ATP6N1C; ATP6V0A3; OC-116kDa; OC116; OPTB1; Stv1; TIRC7; Vph1
Species Homo sapiens
Ensembl Gene ENSG00000110719
Encoded Proteins
IDBP-61187
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
IDBP-587291
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
IDBP-597376
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
IDBP-602861
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
IDBP-586215
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
IDBP-601074
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
IDBP-594114
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
IDBP-598333
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Through alternate splicing, this gene encodes two proteins with similarity to subunits of the vacuolar ATPase (V-ATPase) but the encoded proteins seem to have different functions. V-ATPase is a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Mutations in this gene are associated with infantile malignant osteopetrosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:68039016-68050895
Strand Forward strand
Band q13.2
Transcripts
ENST00000265686 ENSP00000265686
ENST00000534673 ENSP00000431174
ENST00000524598 ENSP00000432846
ENST00000529657 ENSP00000435023
ENST00000533947
ENST00000532635 ENSP00000434407
ENST00000527530
ENST00000529364 ENSP00000431437
ENST00000525724
ENST00000528981 ENSP00000436082
ENST00000533005
ENST00000525516
ENST00000524870
ENST00000530063 ENSP00000432957
ENST00000530449
ENST00000530802
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0015078 hydrogen ion transmembrane transporter activity
Biological Process
GO:0006879 cellular iron ion homeostasis
GO:0006968 cellular defense response
GO:0008284 positive regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0015991 ATP hydrolysis coupled proton transport
GO:0015992 proton transport
GO:0033572 transferrin transport
GO:0051701 interaction with host
GO:0055085 transmembrane transport
GO:0090382 phagosome maturation
Cellular Component
GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain
GO:0005739 mitochondrion
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0010008 endosome membrane
GO:0016324 apical plasma membrane
GO:0030670 phagocytic vesicle membrane
GO:0033179 proton-transporting V-type ATPase, V0 domain
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001750
View Gene Order
ENSBTAG00000000292
Not yet available
Pathways
NETPATH
REACTOME
REACT_25283
Transferrin endocytosis and recycling pathway
REACT_25060
Iron uptake and transport pathway
REACT_1109
Insulin receptor recycling pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_121256
Phagosomal maturation (early endosomal stage) pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_111102
Signal Transduction pathway
REACT_121237
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
REACT_116125
Disease pathway
KEGG
hsa05110
Vibrio cholerae infection pathway
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa00190
Oxidative phosphorylation pathway
hsa04142
Lysosome pathway
hsa04966
Collecting duct acid secretion pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt Q13488
TrEMBL A0A024R5E5 E9PM12 E9PMC5 E9PNA6 Q6QBN6 Q8TCH1
UniProt Splice Variant
Entrez Gene 10312
UniGene Hs.495985 Hs.735698
RefSeq NM_006019 NM_006053 XM_005273709 XM_005273710 XM_006718417
HUGO HGNC:11647
OMIM 604592
CCDS CCDS53670 CCDS8177
HPRD
IMGT
EMBL AF025374 AF033033 AF497545 AP002807 AY548969 BC018133 BC032465 CH471076 U45285
GenPept AAA97878 AAC35742 AAD31081 AAH18133 AAH32465 AAM18704 AAS59836 EAW74691 EAW74692
RNA Seq Atlas 10312

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca