InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TCIRG1

Summary

InnateDB Gene

IDBG-644840.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TCIRG1

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000292

Encoded Proteins

IDBP-697508

T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110719:
Through alternate splicing, this gene encodes two proteins with similarity to subunits of the vacuolar ATPase (V-ATPase) but the encoded proteins seem to have different functions. V-ATPase is a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Mutations in this gene are associated with infantile malignant osteopetrosis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:46214074-46223038

Strand

Forward strand

Band

Transcripts

ENSBTAT00000000367

ENSBTAP00000000367

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015078	hydrogen ion transmembrane transporter activity

Biological Process

GO:0015991

ATP hydrolysis coupled proton transport

Cellular Component

GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain
GO:0005739	mitochondrion
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0016324	apical plasma membrane
GO:0033179	proton-transporting V-type ATPase, V0 domain