InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ttr

Summary

InnateDB Gene

IDBG-130236.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ttr

Gene Name

transthyretin

Synonyms

AA408768; AI787086; D17860; prealbumin

Species

Mus musculus

Ensembl Gene

ENSMUSG00000061808

Encoded Proteins

IDBP-130238

transthyretin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a carrier protein responsible for the transport of thyroid hormones and retinol. The protein consists of a tetramer of identical subunits. Due to increased stability of the tetramer form of this encoded protein in mouse, compared to the human protein, this gene product has a reduced tendency to form amyloid fibrils. In humans, this protein binds beta-amyloid preventing its aggregation and providing a neuroprotective role in Alzheimer's disease. [provided by RefSeq, Mar 2010]
This gene encodes a carrier protein responsible for the transport of thyroid hormones and retinol. The protein consists of a tetramer of identical subunits. Due to increased stability of the tetramer form of this encoded protein in mouse, compared to the human protein, this gene product has a reduced tendency to form amyloid fibrils. In humans, this protein binds beta-amyloid preventing its aggregation and providing a neuroprotective role in Alzheimer\'s disease. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:20665250-20674324

Strand

Forward strand

Band

Transcripts

ENSMUST00000075312

ENSMUSP00000074783

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	4 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	45 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0042562	hormone binding
GO:0042802	identical protein binding
GO:0046982	protein heterodimerization activity