Version 5.4
| Bos taurus Gene: TTR | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-643739.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | TTR | ||||||||
| Gene Name | Transthyretin | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000010991 | ||||||||
| Encoded Proteins |
Transthyretin
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118271:
This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 24:25854675-25863535 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||
| NETPATH | |||||||||
| REACTOME |
Non-integrin membrane-ECM interactions pathway
Amyloids pathway
Extracellular matrix organization pathway
Retinoid metabolism and transport pathway
The canonical retinoid cycle in rods (twilight vision) pathway
Visual phototransduction pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
Retinoid cycle disease events pathway
Disease pathway
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| KEGG | |||||||||
| INOH | |||||||||
| PID NCI | |||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
The canonical retinoid cycle in rods (twilight vision) pathway
Retinoid metabolism and transport pathway
Amyloids pathway
Retinoid cycle disease events pathway
Extracellular matrix organization pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
Non-integrin membrane-ECM interactions pathway
Visual phototransduction pathway
Disease pathway
Disease pathway
Retinoid metabolism and transport pathway
Amyloids pathway
Extracellular matrix organization pathway
The canonical retinoid cycle in rods (twilight vision) pathway
Non-integrin membrane-ECM interactions pathway
Visual phototransduction pathway
Retinoid cycle disease events pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
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| KEGG | |||||||||
| INOH | |||||||||
| PID NCI |
FOXA2 and FOXA3 transcription factor networks
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| Cross-References | |||||||||
| SwissProt | O46375 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 280948 | ||||||||
| UniGene | Bt.207 | ||||||||
| RefSeq | NM_173967 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AB009591 BC103035 | ||||||||
| GenPept | AAI03036 BAA23983 | ||||||||
| RNA Seq Atlas | 280948 | ||||||||