Version 5.4
Mus musculus Gene: Dpp3
Summary
InnateDB Gene IDBG-130319.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dpp3
Gene Name dipeptidylpeptidase 3
Synonyms 4930533O14Rik; C86324
Species Mus musculus
Ensembl Gene ENSMUSG00000063904
Encoded Proteins
IDBP-130321
dipeptidylpeptidase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000254986:
This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:4907229-4928287
Strand Reverse strand
Band A
Transcripts
ENSMUST00000025851 ENSMUSP00000025851
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008239 dipeptidyl-peptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000254986
View Gene Order
ENSBTAG00000022242
Not yet available
Cross-References
SwissProt Q99KK7
TrEMBL Q3UDY7
UniProt Splice Variant
Entrez Gene 75221
UniGene Mm.234769
RefSeq NM_133803 XM_006531854
OMIM
CCDS CCDS29443
HPRD
IMGT
MGI ID MGI:1922471
MGI Symbol Dpp3
EMBL AK031020 AK149853 AK166842 BC004600
GenPept AAH04600 BAC27216 BAE29124 BAE39063
RNA Seq Atlas 75221

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca