Version 5.4
Homo sapiens Gene: DKFZP686D09174
Summary
InnateDB Gene IDBG-545594.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DKFZP686D09174
Gene Name Proteasome subunit alpha type-2
Synonyms HC3; MU; PMSA2; PSC2
Species Homo sapiens
Ensembl Gene ENSG00000256646
Encoded Proteins
IDBP-718027
IDBP-718440
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:42909273-42932174
Strand Reverse strand
Band p14.1
Transcripts
ENST00000442788 ENSP00000455744
ENST00000433579 ENSP00000456999
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004298 threonine-type endopeptidase activity
GO:0005515 protein binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000209 protein polyubiquitination
GO:0000278 mitotic cell cycle
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006521 regulation of cellular amino acid metabolic process
GO:0006915 apoptotic process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0009615 response to virus
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0044281 small molecule metabolic process
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051603 proteolysis involved in cellular protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0000932 cytoplasmic mRNA processing body
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005839 proteasome core complex
GO:0019773 proteasome core complex, alpha-subunit complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015671
View Gene Order
ENSBTAG00000000990
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03050
Proteasome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A0A024RA52 Q6MZI6
UniProt Splice Variant
Entrez Gene 5683
UniGene
RefSeq
HUGO HGNC:9531
OMIM 176842
CCDS CCDS5467
HPRD 08907
IMGT
EMBL AC010132 AK290654 BC002900 BC047697 BX641097 CH236951 CH471073 CR450317 D00760
GenPept AAH02900 AAH47697 BAA00657 BAF83343 CAE46046 CAG29313 EAL24005 EAW94151 EAW94152 EAW94153
RNA Seq Atlas 5683

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca