InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Usp7

Summary

InnateDB Gene

IDBG-131871.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Usp7

Gene Name

ubiquitin specific peptidase 7

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022710

Encoded Proteins

IDBP-533588

ubiquitin specific peptidase 7

IDBP-541843

ubiquitin specific peptidase 7

IDBP-533967

ubiquitin specific peptidase 7

IDBP-624705

ubiquitin specific peptidase 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18952891

[Homo sapiens] Cytoplasmic USP7 binds to and deubiquitinates TRAF6 and IKBKG, thus terminating TLR-mediated NF-kappaB and JNK activation

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187555:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:8689595-8792308

Strand

Reverse strand

Band

Transcripts

ENSMUST00000160405	ENSMUSP00000124382
ENSMUST00000160326	ENSMUSP00000124576
ENSMUST00000161046	ENSMUSP00000124093
ENSMUST00000162445
ENSMUST00000162929
ENSMUST00000159387
ENSMUST00000159281
ENSMUST00000159287
ENSMUST00000162141
ENSMUST00000159503
ENSMUST00000159509
ENSMUST00000173939
ENSMUST00000172505	ENSMUSP00000133398

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 175 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	175 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0004197	cysteine-type endopeptidase activity
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008134	transcription factor binding
GO:0008234	cysteine-type peptidase activity
GO:0031625	ubiquitin protein ligase binding
GO:0036459	ubiquitinyl hydrolase activity

Biological Process

GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0010216	maintenance of DNA methylation
GO:0016579	protein deubiquitination
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000187555

View Gene Order

ENSBTAG00000005455

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

foxopathway

FoxO family signaling

p53regulationpathway

p53 pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.295330 Mm.403422 Mm.409877 Mm.486702

RefSeq

NM_001003918 XM_006522138 XM_006522139 XM_006522140 XM_006522141

OMIM

CCDS

CCDS49755

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas