InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Coq3

Summary

InnateDB Gene

IDBG-131969.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Coq3

Gene Name

coenzyme Q3 homolog, methyltransferase (yeast)

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028247

Encoded Proteins

IDBP-131971

coenzyme Q3 homolog, methyltransferase (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132423:
Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:21879673-21912162

Strand

Forward strand

Band

Transcripts

ENSMUST00000029909	ENSMUSP00000029909
ENSMUST00000142244

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004395	hexaprenyldihydroxybenzoate methyltransferase activity
GO:0008168	methyltransferase activity
GO:0008276	protein methyltransferase activity
GO:0008425	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
GO:0008689	3-demethylubiquinone-9 3-O-methyltransferase activity
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity

Biological Process

GO:0006071	glycerol metabolic process
GO:0006479	protein methylation
GO:0006744	ubiquinone biosynthetic process
GO:0008152	metabolic process
GO:0008610	lipid biosynthetic process
GO:0009312	oligosaccharide biosynthetic process
GO:0009877	nodulation
GO:0032259	methylation

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000132423

View Gene Order

ENSBTAG00000019729

Not yet available

Pathways

NETPATH

REACTOME

REACT_188937

Metabolism pathway

REACT_232291

Metabolism of lipids and lipoproteins pathway

REACT_196568

Ubiquinol biosynthesis pathway

KEGG

mmu00130

Ubiquinone and other terpenoid-quinone biosynthesis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_160111

Ubiquinol biosynthesis pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_111217

Metabolism pathway

KEGG

hsa00130

Ubiquinone and other terpenoid-quinone biosynthesis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.5662

RefSeq

NM_172687

OMIM

CCDS

CCDS18003

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas