InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: COQ3

Summary

InnateDB Gene

IDBG-94570.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COQ3

Gene Name

coenzyme Q3 homolog, methyltransferase (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000132423

Encoded Proteins

IDBP-94572

coenzyme Q3 homolog, methyltransferase (S. cerevisiae)

IDBP-94574

coenzyme Q3 homolog, methyltransferase (S. cerevisiae)

IDBP-94576

coenzyme Q3 homolog, methyltransferase (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:99369400-99394204

Strand

Reverse strand

Band

q16.2

Transcripts

ENST00000254759	ENSP00000254759
ENST00000369242	ENSP00000358245
ENST00000369240	ENSP00000358243
ENST00000479163

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004395	hexaprenyldihydroxybenzoate methyltransferase activity
GO:0008168	methyltransferase activity
GO:0008171	O-methyltransferase activity
GO:0008276	protein methyltransferase activity
GO:0008425	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
GO:0008689	3-demethylubiquinone-9 3-O-methyltransferase activity
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity

Biological Process

GO:0006071	glycerol metabolic process
GO:0006479	protein methylation
GO:0006744	ubiquinone biosynthetic process
GO:0008152	metabolic process
GO:0008610	lipid biosynthetic process
GO:0009312	oligosaccharide biosynthetic process
GO:0009877	nodulation
GO:0032259	methylation
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028247

View Gene Order

ENSBTAG00000019729

Not yet available

Pathways

NETPATH

REACTOME

REACT_160111

Ubiquinol biosynthesis pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_111217

Metabolism pathway

KEGG

hsa00130

Ubiquinone and other terpenoid-quinone biosynthesis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

Q5T063

UniProt Splice Variant

Entrez Gene

51805

UniGene

Hs.713623

RefSeq

XM_005267018 NM_017421 XM_006715501

HUGO

HGNC:18175

OMIM

605196

CCDS

CCDS5042

HPRD

07283

IMGT

EMBL

AL513550

GenPept

RNA Seq Atlas

51805