Version 5.4
Mus musculus Gene: Pik3c3
Summary
InnateDB Gene IDBG-132410.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pik3c3
Gene Name phosphoinositide-3-kinase, class 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000033628
Encoded Proteins
IDBP-132412
phosphoinositide-3-kinase, class 3
IDBP-248808
phosphoinositide-3-kinase, class 3
IDBP-248810
phosphoinositide-3-kinase, class 3
IDBP-621657
phosphoinositide-3-kinase, class 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22170068
Class III phosphatidylinositol 3-kinases (PI3K) are required for downstream Arf6 regulation of CpG oligodeoxynucleotide uptake and thus have a role in Tlr9-mediated immune signalling.
PMID 25586187
Super-low dose lipopolysaccharide induces inhibitory phosphorylation of Pik3c3 leading to the disruption of endosome-lysosome fusion and low-grade inflammation in innate macrophages; a mechanism that depends on the clearance and relocation of Tollip.
InnateDB Annotation from Orthologs
Summary
PMID 22170068
[Homo sapiens] Class III phosphatidylinositol 3-kinases (PI3K) are required for downstream ARF6 regulation of CpG oligodeoxynucleotide uptake and thus have a role in TLR9-mediated immune signalling.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000078142:
Gene Information
Type Protein coding
Genomic Location Chromosome 18:30272747-30348126
Strand Forward strand
Band B1
Transcripts
ENSMUST00000091978 ENSMUSP00000089601
ENSMUST00000115812 ENSMUSP00000111479
ENSMUST00000115811 ENSMUSP00000111478
ENSMUST00000131405 ENSMUSP00000128927
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0035004 phosphatidylinositol 3-kinase activity
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0000910 cytokinesis
GO:0006468 protein phosphorylation
GO:0007032 endosome organization
GO:0016485 protein processing
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0043201 response to leucine
GO:0045022 early endosome to late endosome transport
GO:0045087 innate immune response (InnateDB)
GO:0046854 phosphatidylinositol phosphorylation
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050708 regulation of protein secretion
Cellular Component
GO:0005770 late endosome
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0016020 membrane
GO:0030496 midbody
GO:0045335 phagocytic vesicle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000078142
View Gene Order
ENSBTAG00000026290
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_198975
Synthesis of PIPs at the early endosome membrane pathway
REACT_198972
Synthesis of PIPs at the late endosome membrane pathway
REACT_198970
Synthesis of PIPs at the Golgi membrane pathway
REACT_240250
Signaling by Insulin receptor pathway
REACT_199016
PI Metabolism pathway
REACT_188937
Metabolism pathway
REACT_230745
Immune System pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_249409
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_259732
Insulin receptor signalling cascade pathway
REACT_188215
IRS-related events triggered by IGF1R pathway
REACT_188218
IGF1R signaling cascade pathway
REACT_188219
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_240139
PI3K Cascade pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_188643
Phospholipid metabolism pathway
REACT_243154
IRS-related events pathway
REACT_242206
IRS-mediated signalling pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04140
Regulation of autophagy pathway
mmu04070
Phosphatidylinositol signaling system pathway
mmu00562
Inositol phosphate metabolism pathway
mmu04145
Phagosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_120756
Synthesis of PIPs at the early endosome membrane pathway
REACT_120836
Synthesis of PIPs at the Golgi membrane pathway
REACT_120918
Synthesis of PIPs at the late endosome membrane pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_6802
Innate Immune System pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_111102
Signal Transduction pathway
REACT_332
IRS-mediated signalling pathway
REACT_6900
Immune System pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_762
IRS-related events pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_111217
Metabolism pathway
KEGG
hsa04140
Regulation of autophagy pathway
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
hsa04145
Phagosome pathway
INOH
INOH website
Inositol phosphate metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL E9Q824
UniProt Splice Variant
Entrez Gene 225326
UniGene Mm.194127
RefSeq NM_181414 XM_006525839
OMIM
CCDS CCDS37752
HPRD
IMGT
MGI ID MGI:2445019
MGI Symbol Pik3c3
EMBL AC163399
GenPept
RNA Seq Atlas 225326

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca