Version 5.4
Mus musculus Gene: Socs1
Summary
InnateDB Gene IDBG-132667.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Socs1
Gene Name suppressor of cytokine signaling 1
Synonyms Cish1; Cish7; JAB; SOCS-1; SSI-1
Species Mus musculus
Ensembl Gene ENSMUSG00000038037
Encoded Proteins
IDBP-132669
suppressor of cytokine signaling 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21263070
Socs1 is a negative immunomodulator that is upregulated by Hepatitis C virus to deliver negative signaling to Tlr-mediated pathways controlling expression of Il12, a key cytokine linking innate and adaptive immunity.
PMID 21606371
Socs1 is targeted by endogenous and pharmacologic glucocorticoids to limit Tlr3/Tlr4-mediated Stat1 activation which results in the suppression of inflammation.
PMID 21757742
Socs1 inhibits type I interferon (IFN) signaling through an interaction with the Ifnar1 associated kinase, Tyk2, resulting in a reduced IFN response and reduced Ifnar1 surface expression. (Demonstrated in human)
InnateDB Annotation from Orthologs
Summary
PMID 16451196
[Homo sapiens] SOCS1 is a potent and multifaceted regulator of cytokines and cell-mediated inflammation.
PMID 19017994
[Homo sapiens] SOCS1 regulates the IFN but Not NF{kappa}B Pathway in TLR-Stimulated Human monocytes and macrophages.
PMID 21263070
[Homo sapiens] SOCS1 is a negative immunomodulator that is upregulated by Hepatitis C virus to deliver negative signalling to TLR-mediated pathways controlling expression of IL12, a key cytokine linking innate and adaptive immunity.
PMID 21606371
[Homo sapiens] SOCS1 is targeted by endogenous and pharmacologic glucocorticoids to limit TLR3/TLR4-mediated STAT1 activation which results in the suppression of inflammation. (Demonstrated in murine model)
PMID 21757742
[Homo sapiens] SOCS1 inhibits type I interferon (IFN) signaling through an interaction with the IFNAR1 associated kinase, TYK2, resulting in a reduced IFN response and reduced IFNAR1 surface expression.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185338:
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:10783808-10785536
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000038099 ENSMUSP00000038121
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.
Experimentally validated
Total 62 [view]
Protein-Protein 55 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 60 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005159 insulin-like growth factor receptor binding
GO:0005515 protein binding
GO:0019210 kinase inhibitor activity
GO:0019901 protein kinase binding
Biological Process
GO:0001932 regulation of protein phosphorylation
GO:0007259 JAK-STAT cascade
GO:0016567 protein ubiquitination
GO:0019221 cytokine-mediated signaling pathway
GO:0035556 intracellular signal transduction
GO:0040008 regulation of growth
GO:0042518 negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0045087 innate immune response (InnateDB)
GO:0045444 fat cell differentiation
GO:0046426 negative regulation of JAK-STAT cascade
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0071230 cellular response to amino acid stimulus
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0016023 cytoplasmic membrane-bounded vesicle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000185338
View Gene Order
ENSBTAG00000004386
Not yet available
Pathways
NETPATH
REACTOME
REACT_263004
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_239142
Innate Immune System pathway
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_227425
Regulation of KIT signaling pathway
REACT_188578
Signaling by SCF-KIT pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_255939
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_230745
Immune System pathway
REACT_254406
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_199115
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_198645
Regulation of IFNG signaling pathway
REACT_198660
Interferon gamma signaling pathway
REACT_198666
Interferon Signaling pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_229531
Adaptive Immune System pathway
REACT_262462
Activated TLR4 signalling pathway
REACT_198614
Growth hormone receptor signaling pathway
REACT_188257
Signal Transduction pathway
REACT_230045
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_198627
Regulation of IFNA signaling pathway
REACT_198622
Interferon alpha/beta signaling pathway
REACT_246719
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
mmu04120
Ubiquitin mediated proteolysis pathway
mmu04930
Type II diabetes mellitus pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu04910
Insulin signaling pathway pathway
mmu04380
Osteoclast differentiation pathway
mmu05145
Toxoplasmosis pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
Growth hormone signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_14
IL2 pathway
NetPath_16
IL4 pathway
NetPath_17
IL5 pathway
NetPath_23
TSH pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_111133
Growth hormone receptor signaling pathway
REACT_25216
Regulation of IFNA signaling pathway
REACT_25162
Interferon alpha/beta signaling pathway
REACT_24980
Regulation of IFNG signaling pathway
REACT_25078
Interferon gamma signaling pathway
REACT_111225
Regulation of KIT signaling pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_111102
Signal Transduction pathway
REACT_25229
Interferon Signaling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04910
Insulin signaling pathway pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa04930
Type II diabetes mellitus pathway
hsa04380
Osteoclast differentiation pathway
hsa05145
Toxoplasmosis pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
Growth hormone signaling pathway
PID NCI
il2_1pathway
IL2-mediated signaling events
il12_2pathway
IL12-mediated signaling events
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
il4_2pathway
IL4-mediated signaling events
ifngpathway
IFN-gamma pathway
Cross-References
SwissProt O35716
TrEMBL
UniProt Splice Variant
Entrez Gene 12703
UniGene Mm.130
RefSeq NM_001271603 NM_009896
OMIM
CCDS CCDS27952
HPRD
IMGT
MGI ID MGI:1354910
MGI Symbol Socs1
EMBL AB000677 AB000710 AF120490 AF180302 AK028632 AK154706 BC132366 BC132368 U88325
GenPept AAB62400 AAD24777 AAD53324 AAI32367 AAI32369 BAA21538 BAA21539 BAC26040 BAE32775
RNA Seq Atlas 12703

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca