Bos taurus Gene: SOCS1 | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-648701.3 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | SOCS1 | ||||||||||||||||||||||
Gene Name | Uncharacterized protein | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000004386 | ||||||||||||||||||||||
Encoded Proteins |
suppressor of cytokine signaling 1
|
||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||||||
Summary |
[Homo sapiens] SOCS1 is a potent and multifaceted regulator of cytokines and cell-mediated inflammation.
[Homo sapiens] SOCS1 regulates the IFN but Not NF{kappa}B Pathway in TLR-Stimulated Human monocytes and macrophages.
[Homo sapiens] SOCS1 is a negative immunomodulator that is upregulated by Hepatitis C virus to deliver negative signalling to TLR-mediated pathways controlling expression of IL12, a key cytokine linking innate and adaptive immunity.
[Homo sapiens] SOCS1 is targeted by endogenous and pharmacologic glucocorticoids to limit TLR3/TLR4-mediated STAT1 activation which results in the suppression of inflammation. (Demonstrated in murine model)
[Homo sapiens] SOCS1 inhibits type I interferon (IFN) signaling through an interaction with the IFNAR1 associated kinase, TYK2, resulting in a reduced IFN response and reduced IFNAR1 surface expression.
[Mus musculus] Socs1 is a negative immunomodulator that is upregulated by Hepatitis C virus to deliver negative signaling to Tlr-mediated pathways controlling expression of Il12, a key cytokine linking innate and adaptive immunity.
[Mus musculus] Socs1 is targeted by endogenous and pharmacologic glucocorticoids to limit Tlr3/Tlr4-mediated Stat1 activation which results in the suppression of inflammation.
[Mus musculus] Socs1 inhibits type I interferon (IFN) signaling through an interaction with the Ifnar1 associated kinase, Tyk2, resulting in a reduced IFN response and reduced Ifnar1 surface expression. (Demonstrated in human)
|
||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185338:
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008] |
||||||||||||||||||||||
Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 25:9975299-9975970 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | |||||||||||||||||||||||
Transcripts |
|
||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 79 interaction(s) predicted by orthology.
|
||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||
Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
|
Gene ID
Gene Order
|
||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH |
EGFR1 pathway
KitReceptor pathway
IL2 pathway
IL4 pathway
IL5 pathway
TSH pathway
Prolactin pathway
|
||||||||||||||||||||||
REACTOME |
Antigen processing: Ubiquitination & Proteasome degradation pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Growth hormone receptor signaling pathway
Regulation of IFNA signaling pathway
Interferon alpha/beta signaling pathway
Regulation of IFNG signaling pathway
Interferon gamma signaling pathway
Regulation of KIT signaling pathway
Signaling by SCF-KIT pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Signal Transduction pathway
Interferon Signaling pathway
Adaptive Immune System pathway
Immune System pathway
Activated TLR4 signalling pathway
Class I MHC mediated antigen processing & presentation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Class I MHC mediated antigen processing & presentation pathway
Regulation of KIT signaling pathway
Signaling by SCF-KIT pathway
Cytokine Signaling in Immune system pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Immune System pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Regulation of IFNG signaling pathway
Interferon gamma signaling pathway
Interferon Signaling pathway
Toll-Like Receptors Cascades pathway
Adaptive Immune System pathway
Activated TLR4 signalling pathway
Growth hormone receptor signaling pathway
Signal Transduction pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Regulation of IFNA signaling pathway
Interferon alpha/beta signaling pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
|
||||||||||||||||||||||
KEGG |
Ubiquitin mediated proteolysis pathway
Insulin signaling pathway pathway
Jak-STAT signaling pathway pathway
Type II diabetes mellitus pathway
Osteoclast differentiation pathway
Toxoplasmosis pathway
Ubiquitin mediated proteolysis pathway
Type II diabetes mellitus pathway
Jak-STAT signaling pathway pathway
Insulin signaling pathway pathway
Osteoclast differentiation pathway
Toxoplasmosis pathway
|
||||||||||||||||||||||
INOH |
JAK STAT pathway and regulation pathway
Growth hormone signaling pathway
JAK STAT pathway and regulation pathway
Growth hormone signaling pathway
|
||||||||||||||||||||||
PID NCI |
IL2-mediated signaling events
IL12-mediated signaling events
Signaling events mediated by Stem cell factor receptor (c-Kit)
IL4-mediated signaling events
IFN-gamma pathway
|
||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | F1MSN0 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 518795 | ||||||||||||||||||||||
UniGene | Bt.1736 | ||||||||||||||||||||||
RefSeq | XM_002697964 XM_864316 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | |||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | DAAA02057473 GJ062847 JX155782 | ||||||||||||||||||||||
GenPept | AFP96994 DAA15735 | ||||||||||||||||||||||
RNA Seq Atlas | 518795 | ||||||||||||||||||||||