InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SOCS1

Summary

InnateDB Gene

IDBG-14621.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SOCS1

Gene Name

suppressor of cytokine signaling 1

Synonyms

CIS1; CISH1; JAB; SOCS-1; SSI-1; SSI1; TIP3

Species

Homo sapiens

Ensembl Gene

ENSG00000185338

Encoded Proteins

IDBP-14623

suppressor of cytokine signaling 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 16451196

SOCS1 is a potent and multifaceted regulator of cytokines and cell-mediated inflammation.

PMID 19017994

SOCS1 regulates the IFN but Not NF{kappa}B Pathway in TLR-Stimulated Human monocytes and macrophages.

PMID 21263070

SOCS1 is a negative immunomodulator that is upregulated by Hepatitis C virus to deliver negative signalling to TLR-mediated pathways controlling expression of IL12, a key cytokine linking innate and adaptive immunity.

PMID 21606371

SOCS1 is targeted by endogenous and pharmacologic glucocorticoids to limit TLR3/TLR4-mediated STAT1 activation which results in the suppression of inflammation. (Demonstrated in murine model)

PMID 21757742

SOCS1 inhibits type I interferon (IFN) signaling through an interaction with the IFNAR1 associated kinase, TYK2, resulting in a reduced IFN response and reduced IFNAR1 surface expression.

InnateDB Annotation from Orthologs

Summary

PMID 21263070

[Mus musculus] Socs1 is a negative immunomodulator that is upregulated by Hepatitis C virus to deliver negative signaling to Tlr-mediated pathways controlling expression of Il12, a key cytokine linking innate and adaptive immunity.

PMID 21606371

[Mus musculus] Socs1 is targeted by endogenous and pharmacologic glucocorticoids to limit Tlr3/Tlr4-mediated Stat1 activation which results in the suppression of inflammation.

PMID 21757742

[Mus musculus] Socs1 inhibits type I interferon (IFN) signaling through an interaction with the Ifnar1 associated kinase, Tyk2, resulting in a reduced IFN response and reduced Ifnar1 surface expression. (Demonstrated in human)

Entrez Gene

Summary

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:11254405-11256179

Strand

Reverse strand

Band

p13.13

Transcripts

ENST00000332029

ENSP00000329418

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 84 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	84 [view]
Protein-Protein	75 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004860	protein kinase inhibitor activity
GO:0005159	insulin-like growth factor receptor binding
GO:0005515	protein binding
GO:0019210	kinase inhibitor activity
GO:0019901	protein kinase binding

Biological Process

GO:0001932	regulation of protein phosphorylation
GO:0006469	negative regulation of protein kinase activity
GO:0007259	JAK-STAT cascade
GO:0016567	protein ubiquitination
GO:0019221	cytokine-mediated signaling pathway
GO:0035556	intracellular signal transduction
GO:0040008	regulation of growth
GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0045087	innate immune response (InnateDB)
GO:0045444	fat cell differentiation
GO:0046426	negative regulation of JAK-STAT cascade
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060334	regulation of interferon-gamma-mediated signaling pathway
GO:0060337	type I interferon signaling pathway
GO:0060338	regulation of type I interferon-mediated signaling pathway
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0071230	cellular response to amino acid stimulus