Mus musculus Gene: Gpx5
Summary
InnateDB Gene IDBG-133384.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gpx5
Gene Name glutathione peroxidase 5
Synonyms Arep; AV379049
Species Mus musculus
Ensembl Gene ENSMUSG00000004344
Encoded Proteins
glutathione peroxidase 5
glutathione peroxidase 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000224586:
This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike mRNAs for other characterized glutathione peroxidases, this mRNA does not contain a selenocysteine (UGA) codon. Thus, the encoded protein is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:21286429-21292731
Strand Reverse strand
Band A3.1
Transcripts
ENSMUST00000004456 ENSMUSP00000004456
ENSMUST00000110491 ENSMUSP00000106117
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004602 glutathione peroxidase activity
Biological Process
GO:0006979 response to oxidative stress
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
Glutathione metabolism pathway
Arachidonic acid metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Arachidonic acid metabolism pathway
Glutathione metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F2Z3Y2 Q8CC60
UniProt Splice Variant
Entrez Gene 14780
UniGene Mm.1332
RefSeq NM_010343
OMIM
CCDS CCDS26270
HPRD
IMGT
MGI ID MGI:104886
MGI Symbol Gpx5
EMBL AC124460 AK033841 BX001068 M68896 X53780
GenPept AAA37729 BAC28492 CAA37796
RNA Seq Atlas 14780