InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MYO10

Summary

InnateDB Gene

IDBG-13359.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYO10

Gene Name

myosin X

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000145555

Encoded Proteins

IDBP-13361

myosin X

IDBP-481784

myosin X

IDBP-476931

myosin X

IDBP-478386

myosin X

IDBP-485258

myosin X

IDBP-475206

myosin X

IDBP-480257

myosin X

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:16661914-16936276

Strand

Reverse strand

Band

p15.1

Transcripts

ENST00000274203	ENSP00000274203
ENST00000513610	ENSP00000421280
ENST00000515803	ENSP00000425051
ENST00000505695	ENSP00000421170
ENST00000513882	ENSP00000421309
ENST00000506343
ENST00000512061
ENST00000510401
ENST00000508318
ENST00000511972
ENST00000502436	ENSP00000426783
ENST00000507288	ENSP00000426664

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0030507	spectrin binding
GO:0030898	actin-dependent ATPase activity
GO:0051015	actin filament binding
GO:0060002	plus-end directed microfilament motor activity

Biological Process

GO:0006200	ATP catabolic process
GO:0007165	signal transduction
GO:0007411	axon guidance
GO:0008152	metabolic process
GO:0008360	regulation of cell shape
GO:0022409	positive regulation of cell-cell adhesion
GO:0030705	cytoskeleton-dependent intracellular transport
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087	innate immune response
GO:0051489	regulation of filopodium assembly

Cellular Component

GO:0001726	ruffle
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0016459	myosin complex
GO:0030027	lamellipodium
GO:0030175	filopodium
GO:0031527	filopodium membrane
GO:0032433	filopodium tip
GO:0043005	neuron projection
GO:0043025	neuronal cell body

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022272

View Gene Order

ENSBTAG00000020126

Not yet available

Pathways

NETPATH

REACTOME

REACT_160086

Regulation of actin dynamics for phagocytic cup formation pathway

REACT_22237

Netrin-1 signaling pathway

REACT_111045

Developmental Biology pathway

REACT_6802

Innate Immune System pathway

REACT_18266

Axon guidance pathway

REACT_6900

Immune System pathway

REACT_160123

Fcgamma receptor (FCGR) dependent phagocytosis pathway

KEGG

hsa04666

Fc gamma R-mediated phagocytosis pathway

INOH

PID NCI

netrin_pathway

Netrin-mediated signaling events

Cross-References

SwissProt

TrEMBL

E9PCN3 Q6IPD7

UniProt Splice Variant

Entrez Gene

4651

UniGene

Hs.481720 Hs.597126

RefSeq

NM_012334 XM_005248306 XM_005248307

HUGO

HGNC:7593

OMIM

601481

CCDS

CCDS54834

HPRD

03283

IMGT

EMBL

AC010310 AC010607 AC024588 BC071965 BC094838

GenPept

AAH71965 AAH94838

RNA Seq Atlas

4651