Version 5.4
Mus musculus Gene: Pola2
Summary
InnateDB Gene IDBG-133634.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pola2
Gene Name polymerase (DNA directed), alpha 2
Synonyms AI573378
Species Mus musculus
Ensembl Gene ENSMUSG00000024833
Encoded Proteins
IDBP-133636
polymerase (DNA directed), alpha 2
IDBP-619858
polymerase (DNA directed), alpha 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000014138:
Gene Information
Type Protein coding
Genomic Location Chromosome 19:5940543-5964206
Strand Reverse strand
Band A
Transcripts
ENSMUST00000025752 ENSMUSP00000025752
ENSMUST00000165143 ENSMUSP00000128866
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000060 protein import into nucleus, translocation
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
Cellular Component
GO:0005634 nucleus
GO:0005658 alpha DNA polymerase:primase complex
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000014138
View Gene Order
ENSBTAG00000011455
Not yet available
Pathways
NETPATH
REACTOME
REACT_262992
Processive synthesis on the lagging strand pathway
REACT_251075
Removal of the Flap Intermediate pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_233453
Chromosome Maintenance pathway
REACT_258062
Synthesis of DNA pathway
REACT_241296
DNA strand elongation pathway
REACT_224446
Telomere C-strand synthesis initiation pathway
REACT_208887
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
REACT_232628
DNA Replication pathway
REACT_252672
Telomere Maintenance pathway
REACT_188804
Cell Cycle pathway
REACT_254983
Activation of the pre-replicative complex pathway
REACT_259967
Leading Strand Synthesis pathway
REACT_220175
Telomere C-strand (Lagging Strand) Synthesis pathway
REACT_245528
M/G1 Transition pathway
REACT_253002
G1/S Transition pathway
REACT_250573
Mitotic G1-G1/S phases pathway
REACT_252545
Extension of Telomeres pathway
REACT_238214
DNA replication initiation pathway
REACT_245471
Polymerase switching pathway
REACT_206830
E2F mediated regulation of DNA replication pathway
REACT_245263
Lagging Strand Synthesis pathway
REACT_235483
DNA Replication Pre-Initiation pathway
REACT_225604
Polymerase switching on the C-strand of the telomere pathway
REACT_253623
S Phase pathway
KEGG
mmu00240
Pyrimidine metabolism pathway
mmu03030
DNA replication pathway
mmu00230
Purine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_7987
Polymerase switching on the C-strand of the telomere pathway
REACT_7993
Telomere C-strand synthesis initiation pathway
REACT_7961
Telomere C-strand (Lagging Strand) Synthesis pathway
REACT_2244
DNA replication initiation pathway
REACT_70
Removal of the Flap Intermediate pathway
REACT_1385
Processive synthesis on the lagging strand pathway
REACT_1792
Polymerase switching pathway
REACT_1838
Leading Strand Synthesis pathway
REACT_1095
Activation of the pre-replicative complex pathway
REACT_329
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
REACT_471
E2F mediated regulation of DNA replication pathway
REACT_383
DNA Replication pathway
REACT_2014
Synthesis of DNA pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_22172
Chromosome Maintenance pathway
REACT_734
DNA Replication Pre-Initiation pathway
REACT_7970
Telomere Maintenance pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_1725
M/G1 Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_932
DNA strand elongation pathway
REACT_8030
Extension of Telomeres pathway
REACT_312
Lagging Strand Synthesis pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa03030
DNA replication pathway
hsa00230
Purine metabolism pathway
INOH
PID NCI
Cross-References
SwissProt P33611
TrEMBL Q8C2T6 Q9CTS2
UniProt Splice Variant
Entrez Gene 18969
UniGene
RefSeq NM_001164057 NM_008893
OMIM
CCDS CCDS29485 CCDS50362
HPRD
IMGT
MGI ID MGI:99690
MGI Symbol Pola2
EMBL AC127271 AK020656 AK087989 AK150099 BC021424 BC064795 CH466612 D13546
GenPept AAH21424 AAH64795 BAA02746 BAB32165 BAC40078 BAE29306 EDL33190
RNA Seq Atlas 18969

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca