Version 5.4
Mus musculus Gene: Tbl1xr1
Summary
InnateDB Gene IDBG-133682.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tbl1xr1
Gene Name transducin (beta)-like 1X-linked receptor 1
Synonyms 8030499H02Rik; A630076E03Rik; AW539987; C21; C230089I12Rik; DC42; Ira1; TBLR1
Species Mus musculus
Ensembl Gene ENSMUSG00000027630
Encoded Proteins
IDBP-133806
transducin (beta)-like 1X-linked receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177565:
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:22076652-22216594
Strand Forward strand
Band A3
Transcripts
ENSMUST00000063988 ENSMUSP00000067164
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0042393 histone binding
GO:0044212 transcription regulatory region DNA binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0016568 chromatin modification
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060070 canonical Wnt signaling pathway
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005876 spindle microtubule
GO:0017053 transcriptional repressor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000177565
View Gene Order
ENSBTAG00000021910
Not yet available
Pathways
NETPATH
REACTOME
REACT_118837
Rora activates circadian gene expression pathway
REACT_24972
Circadian Clock pathway
REACT_252217
Transcriptional regulation of white adipocyte differentiation pathway
REACT_224594
Organelle biogenesis and maintenance pathway
REACT_200794
Mus musculus biological processes pathway
REACT_218274
Chromatin organization pathway
REACT_189085
Disease pathway
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_241925
Circadian Clock pathway
REACT_198969
Activation of gene expression by SREBF (SREBP) pathway
REACT_198968
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_198352
REV-ERBA represses gene expression pathway
REACT_198351
RORA activates circadian gene expression pathway
REACT_268398
Orphan transporters pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_196589
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_257219
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_202766
Chromatin modifying enzymes pathway
REACT_199382
Signaling by NOTCH1 pathway
REACT_199410
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_199405
Signaling by NOTCH1 in Cancer pathway
REACT_199407
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_199406
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_199409
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_199408
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_205251
Transcriptional activation of mitochondrial biogenesis pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_233572
Gene Expression pathway
REACT_198602
PPARA activates gene expression pathway
REACT_188576
Developmental Biology pathway
REACT_196516
YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway
REACT_196464
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_206529
Generic Transcription Pathway pathway
REACT_188257
Signal Transduction pathway
REACT_211261
Mitochondrial biogenesis pathway
REACT_257106
HDACs deacetylate histones pathway
REACT_231152
Signaling by NOTCH pathway
REACT_196591
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
KEGG
mmu04310
Wnt signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118780
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_147904
Activation of gene expression by SREBF (SREBP) pathway
REACT_147797
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_118659
RORA activates circadian gene expression pathway
REACT_111118
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
REACT_118789
REV-ERBA represses gene expression pathway
REACT_24941
Circadian Clock pathway
REACT_160243
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_160254
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_118713
YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_111045
Developmental Biology pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_267716
Orphan transporters pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_228222
HDACs deacetylate histones pathway
REACT_200608
Transcriptional activation of mitochondrial biogenesis pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_172623
Chromatin organization pathway
REACT_299
Signaling by NOTCH pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_111217
Metabolism pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
KEGG
hsa04310
Wnt signaling pathway pathway
INOH
PID NCI
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
Cross-References
SwissProt Q8BHJ5
TrEMBL
UniProt Splice Variant
Entrez Gene 81004
UniGene Mm.202966 Mm.407876 Mm.413501
RefSeq NM_030732 XM_006535579 XM_006535580
OMIM
CCDS CCDS17266
HPRD
IMGT
MGI ID MGI:2441730
MGI Symbol Tbl1xr1
EMBL AF268195 AK029595 AK033347 AK036064 AK136255 BC018512
GenPept AAG44738 AAH18512 BAC26526 BAC28241 BAC29294 BAE22898
RNA Seq Atlas 81004

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca