Version 5.4
Mus musculus Gene: Capn1
Summary
InnateDB Gene IDBG-133910.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Capn1
Gene Name calpain 1
Synonyms Capa-1; Capa1; mu-calpin
Species Mus musculus
Ensembl Gene ENSMUSG00000024942
Encoded Proteins
IDBP-133912
calpain 1
IDBP-619859
calpain 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000014216:
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:5988546-6015825
Strand Reverse strand
Band A
Transcripts
ENSMUST00000025891 ENSMUSP00000025891
ENSMUST00000164843 ENSMUSP00000127498
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 45 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0006508 proteolysis
GO:0032801 receptor catabolic process
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000014216
View Gene Order
ENSBTAG00000010230
Not yet available
Pathways
NETPATH
REACTOME
REACT_206066
Extracellular matrix organization pathway
REACT_199052
Degradation of the extracellular matrix pathway
KEGG
mmu05010
Alzheimer's disease pathway
mmu04210
Apoptosis pathway
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_21
RANKL pathway
REACTOME
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_223425
Extracellular matrix organization pathway
REACT_201925
Degradation of the extracellular matrix pathway
KEGG
hsa04210
Apoptosis pathway
hsa05010
Alzheimer's disease pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
ptp1bpathway
Signaling events mediated by PTP1B
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.6221
RefSeq NM_001110504 NM_007600
OMIM
CCDS CCDS37893
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca