InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nudt5

Summary

InnateDB Gene

IDBG-134470.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nudt5

Gene Name

nudix (nucleoside diphosphate linked moiety X)-type motif 5

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025817

Encoded Proteins

IDBP-134472

nudix (nucleoside diphosphate linked moiety X)-type motif 5

IDBP-540605

nudix (nucleoside diphosphate linked moiety X)-type motif 5

IDBP-718925

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165609:
Nudix hydrolases, such as NUDT5, eliminate toxic nucleotide derivatives from the cell and regulate the levels of important signaling nucleotides and their metabolites (McLennan, 1999 [PubMed 10373642]).[supplied by OMIM, Mar 2008]
This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:5845019-5871895

Strand

Forward strand

Band

Transcripts

ENSMUST00000026927	ENSMUSP00000026927
ENSMUST00000138549
ENSMUST00000127116	ENSMUSP00000117670
ENSMUST00000128604
ENSMUST00000179748	ENSMUSP00000136233

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0016787	hydrolase activity
GO:0017110	nucleoside-diphosphatase activity
GO:0019144	ADP-sugar diphosphatase activity
GO:0030515	snoRNA binding
GO:0047631	ADP-ribose diphosphatase activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0009191	ribonucleoside diphosphate catabolic process

Cellular Component

GO:0005634	nucleus
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000165609

View Gene Order

ENSBTAG00000019509

Not yet available

Pathways

NETPATH

REACTOME

REACT_188937

Metabolism pathway

REACT_196618

Phosphate bond hydrolysis by NUDT proteins pathway

REACT_245662

Metabolism of nucleotides pathway

KEGG

mmu00230

Purine metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_150237

Phosphate bond hydrolysis by NUDT proteins pathway

REACT_1698

Metabolism of nucleotides pathway

REACT_111217

Metabolism pathway

KEGG

hsa00230

Purine metabolism pathway

INOH

INOH website

Purine nucleotides nucleosides metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.251904 Mm.432123

RefSeq

NM_016918 XM_006497510 XM_006497511 XM_006497512 XM_006497513 XM_006497514

OMIM

CCDS

CCDS15667

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas