InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Grm3

Summary

InnateDB Gene

IDBG-135075.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grm3

Gene Name

glutamate receptor, metabotropic 3

Synonyms

0710001G23Rik; Gprc1c; mGlu3; mGluR3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000003974

Encoded Proteins

IDBP-135077

glutamate receptor, metabotropic 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198822:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:9485236-9725352

Strand

Reverse strand

Band

Transcripts

ENSMUST00000004076

ENSMUSP00000004076

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001641	group II metabotropic glutamate receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005246	calcium channel regulator activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0019233	sensory perception of pain
GO:0035249	synaptic transmission, glutamatergic
GO:0050804	regulation of synaptic transmission
GO:0051930	regulation of sensory perception of pain
GO:0051966	regulation of synaptic transmission, glutamatergic

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0014069	postsynaptic density
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0042734	presynaptic membrane
GO:0043005	neuron projection
GO:0043197	dendritic spine
GO:0045211	postsynaptic membrane
GO:0048786	presynaptic active zone
GO:0097449	astrocyte projection