Bos taurus Gene: GRM3 | |||||||||||||||||||||
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Summary | |||||||||||||||||||||
InnateDB Gene | IDBG-630880.3 | ||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
Gene Symbol | GRM3 | ||||||||||||||||||||
Gene Name | metabotropic glutamate receptor 3 precursor | ||||||||||||||||||||
Synonyms | |||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||
Ensembl Gene | ENSBTAG00000018989 | ||||||||||||||||||||
Encoded Proteins |
metabotropic glutamate receptor 3
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Protein Structure | |||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198822:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||
Genomic Location | Chromosome 4:33769689-34021297 | ||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||
Band | |||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||
NETPATH | |||||||||||||||||||||
REACTOME |
G alpha (i) signalling events pathway
Class C/3 (Metabotropic glutamate/pheromone receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
Class C/3 (Metabotropic glutamate/pheromone receptors) pathway
GPCR downstream signaling pathway
Signaling by GPCR pathway
GPCR ligand binding pathway
G alpha (i) signalling events pathway
Signal Transduction pathway
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KEGG |
Neuroactive ligand-receptor interaction pathway
Neuroactive ligand-receptor interaction pathway
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INOH |
GPCR signaling pathway
GPCR signaling pathway
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PID NCI | |||||||||||||||||||||
Cross-References | |||||||||||||||||||||
SwissProt | |||||||||||||||||||||
TrEMBL | A5D7D8 | ||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||
Entrez Gene | 541056 | ||||||||||||||||||||
UniGene | Bt.34265 | ||||||||||||||||||||
RefSeq | NM_001098123 | ||||||||||||||||||||
HUGO | |||||||||||||||||||||
OMIM | |||||||||||||||||||||
CCDS | |||||||||||||||||||||
HPRD | |||||||||||||||||||||
IMGT | |||||||||||||||||||||
EMBL | BC140519 DAAA02010271 DAAA02010272 DAAA02010273 DAAA02010274 DAAA02010275 | ||||||||||||||||||||
GenPept | AAI40520 | ||||||||||||||||||||
RNA Seq Atlas | 541056 | ||||||||||||||||||||