Version 5.4
Homo sapiens Gene: GRM3
Summary
InnateDB Gene IDBG-24696.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRM3
Gene Name glutamate receptor, metabotropic 3
Synonyms GLUR3; GPRC1C; mGlu3; MGLUR3
Species Homo sapiens
Ensembl Gene ENSG00000198822
Encoded Proteins
IDBP-24698
glutamate receptor, metabotropic 3
IDBP-380632
glutamate receptor, metabotropic 3
IDBP-380635
glutamate receptor, metabotropic 3
IDBP-380637
glutamate receptor, metabotropic 3
IDBP-380642
glutamate receptor, metabotropic 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:86643914-86864884
Strand Forward strand
Band q21.11
Transcripts
ENST00000361669 ENSP00000355316
ENST00000454217 ENSP00000405427
ENST00000439827 ENSP00000398767
ENST00000421579 ENSP00000390037
ENST00000441140 ENSP00000407490
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001641 group II metabotropic glutamate receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005246 calcium channel regulator activity
GO:0008066 glutamate receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0007268 synaptic transmission
GO:0050804 regulation of synaptic transmission
GO:0051966 regulation of synaptic transmission, glutamatergic
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0014069 postsynaptic density
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0042734 presynaptic membrane
GO:0043005 neuron projection
GO:0043197 dendritic spine
GO:0045211 postsynaptic membrane
GO:0097449 astrocyte projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003974
View Gene Order
ENSBTAG00000018989
Not yet available
Pathways
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_18319
Class C/3 (Metabotropic glutamate/pheromone receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.590575
RefSeq NM_000840 XM_005250290
HUGO
OMIM
CCDS CCDS5600
HPRD 03070
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca