Version 5.4
Mus musculus Gene: Tfdp1
Summary
InnateDB Gene IDBG-135121.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tfdp1
Gene Name transcription factor Dp 1
Synonyms Dp1; Drtf1
Species Mus musculus
Ensembl Gene ENSMUSG00000038482
Encoded Proteins
IDBP-626119
transcription factor Dp 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198176:
This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:13339674-13377702
Strand Forward strand
Band A1.1
Transcripts
ENSMUST00000170909 ENSMUSP00000127952
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019904 protein domain specific binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007049 cell cycle
GO:0008544 epidermis development
GO:0043276 anoikis
GO:0045893 positive regulation of transcription, DNA-templated
GO:2000278 regulation of DNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198176
View Gene Order
ENSBTAG00000019645
Not yet available
Pathways
NETPATH
REACTOME
REACT_217958
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_260005
G1 Phase pathway
REACT_189085
Disease pathway
REACT_208887
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
REACT_215068
Loss of Function of SMAD4 in Cancer pathway
REACT_199110
G0 and Early G1 pathway
REACT_213336
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_224217
TGFBR1 LBD Mutants in Cancer pathway
REACT_188804
Cell Cycle pathway
REACT_258573
Cyclin D associated events in G1 pathway
REACT_204241
Loss of Function of TGFBR2 in Cancer pathway
REACT_216792
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_224787
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_253002
G1/S Transition pathway
REACT_250573
Mitotic G1-G1/S phases pathway
REACT_233572
Gene Expression pathway
REACT_198608
G1/S-Specific Transcription pathway
REACT_223317
Loss of Function of TGFBR1 in Cancer pathway
REACT_209370
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_202264
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_206830
E2F mediated regulation of DNA replication pathway
REACT_206529
Generic Transcription Pathway pathway
REACT_188257
Signal Transduction pathway
REACT_224802
TGFBR1 KD Mutants in Cancer pathway
REACT_212101
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_225428
Signaling by TGF-beta Receptor Complex pathway
REACT_226256
Loss of Function of SMAD2/3 in Cancer pathway
REACT_203903
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
KEGG
mmu04350
TGF-beta signaling pathway pathway
mmu04110
Cell cycle pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_111214
G0 and Early G1 pathway
REACT_683
G1/S-Specific Transcription pathway
REACT_329
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
REACT_471
E2F mediated regulation of DNA replication pathway
REACT_821
Cyclin D associated events in G1 pathway
REACT_120734
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
REACT_118568
Pre-NOTCH Transcription and Translation pathway
REACT_1194
Activation of NOXA and translocation to mitochondria pathway
REACT_121
Activation of PUMA and translocation to mitochondria pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_1590
G1 Phase pathway
REACT_120956
Cellular responses to stress pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_169325
Oncogene Induced Senescence pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_118744
Pre-NOTCH Expression and Processing pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_1783
G1/S Transition pathway
REACT_578
Apoptosis pathway
REACT_111102
Signal Transduction pathway
REACT_121061
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_115566
Cell Cycle pathway
REACT_697
Activation of BH3-only proteins pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_169274
Cellular Senescence pathway
REACT_299
Signaling by NOTCH pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_964
Intrinsic Pathway for Apoptosis pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
REACT_226948
G0 and Early G1 pathway
REACT_227938
Generic Transcription Pathway pathway
REACT_224358
Mitotic G1-G1/S phases pathway
REACT_221739
Loss of Function of TGFBR1 in Cancer pathway
REACT_217678
Signaling by TGF-beta Receptor Complex pathway
REACT_220609
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_218138
Cyclin D associated events in G1 pathway
REACT_211609
G1/S Transition pathway
REACT_210825
G1 Phase pathway
REACT_207152
Loss of Function of SMAD4 in Cancer pathway
REACT_209241
Loss of Function of TGFBR2 in Cancer pathway
REACT_226022
Gene Expression pathway
REACT_215505
Cell Cycle, Mitotic pathway
REACT_201998
E2F mediated regulation of DNA replication pathway
REACT_224304
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
REACT_214934
Cell Cycle pathway
REACT_211897
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_214353
Signal Transduction pathway
REACT_211138
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_223827
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_225533
G1/S-Specific Transcription pathway
REACT_207908
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_224116
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
REACT_207832
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_216195
Loss of Function of SMAD2/3 in Cancer pathway
REACT_220643
TGFBR1 LBD Mutants in Cancer pathway
REACT_207087
Disease pathway
REACT_209664
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_223905
TGFBR1 KD Mutants in Cancer pathway
KEGG
hsa04350
TGF-beta signaling pathway pathway
hsa04110
Cell cycle pathway
INOH
PID NCI
rb_1pathway
Regulation of retinoblastoma protein
p53downstreampathway
Direct p53 effectors
e2f_pathway
E2F transcription factor network
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
Cross-References
SwissProt Q08639
TrEMBL Q3V3X3 Q9CYZ7
UniProt Splice Variant
Entrez Gene 21781
UniGene
RefSeq NM_001291765 NM_001291766 NM_001291768 NM_009361 XM_006508750 XM_006508751 XM_006508752 XM_006508753 XM_006508758
OMIM
CCDS CCDS22110
HPRD
IMGT
MGI ID MGI:101934
MGI Symbol Tfdp1
EMBL AK013180 AK030820 AK154037 BC132567 BC132569 BC145344 CH466566 X72310
GenPept AAI32568 AAI32570 AAI45345 BAB28695 BAE20457 BAE32330 CAA51056 EDL22141
RNA Seq Atlas 21781

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca