Version 5.4
| Bos taurus Gene: TFDP1 | |||||||||||||||||
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| Summary | |||||||||||||||||
| InnateDB Gene | IDBG-634479.3 | ||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
| Gene Symbol | TFDP1 | ||||||||||||||||
| Gene Name | Transcription factor Dp-1 | ||||||||||||||||
| Synonyms | |||||||||||||||||
| Species | Bos taurus | ||||||||||||||||
| Ensembl Gene | ENSBTAG00000019645 | ||||||||||||||||
| Encoded Proteins |
Transcription factor Dp-1
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| Protein Structure | |||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
| Entrez Gene | |||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198176:
This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009] |
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| Gene Information | |||||||||||||||||
| Type | Protein coding | ||||||||||||||||
| Genomic Location | Chromosome 12:90738265-90754997 | ||||||||||||||||
| Strand | Forward strand | ||||||||||||||||
| Band | |||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||||||||||
| NETPATH | |||||||||||||||||
| REACTOME |
G0 and Early G1 pathway
Generic Transcription Pathway pathway
Mitotic G1-G1/S phases pathway
Loss of Function of TGFBR1 in Cancer pathway
Signaling by TGF-beta Receptor Complex pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Cyclin D associated events in G1 pathway
G1/S Transition pathway
G1 Phase pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Gene Expression pathway
Cell Cycle, Mitotic pathway
E2F mediated regulation of DNA replication pathway
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
Cell Cycle pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Signal Transduction pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
G1/S-Specific Transcription pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Disease pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
TGFBR1 KD Mutants in Cancer pathway
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| KEGG | |||||||||||||||||
| INOH | |||||||||||||||||
| PID NCI | |||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||
| NETPATH |
TGF_beta_Receptor pathway
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| REACTOME |
G0 and Early G1 pathway
G1/S-Specific Transcription pathway
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
E2F mediated regulation of DNA replication pathway
Cyclin D associated events in G1 pathway
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
Pre-NOTCH Transcription and Translation pathway
Activation of NOXA and translocation to mitochondria pathway
Activation of PUMA and translocation to mitochondria pathway
Generic Transcription Pathway pathway
G1 Phase pathway
Cellular responses to stress pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Oncogene Induced Senescence pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Pre-NOTCH Expression and Processing pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Mitotic G1-G1/S phases pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
G1/S Transition pathway
Apoptosis pathway
Signal Transduction pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Cell Cycle pathway
Activation of BH3-only proteins pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Cellular Senescence pathway
Signaling by NOTCH pathway
TGFBR1 KD Mutants in Cancer pathway
Cell Cycle, Mitotic pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Intrinsic Pathway for Apoptosis pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Oxidative Stress Induced Senescence pathway
Gene Expression pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Cell Cycle, Mitotic pathway
G1 Phase pathway
Disease pathway
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
Loss of Function of SMAD4 in Cancer pathway
G0 and Early G1 pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Cell Cycle pathway
Cyclin D associated events in G1 pathway
Loss of Function of TGFBR2 in Cancer pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
G1/S Transition pathway
Mitotic G1-G1/S phases pathway
Gene Expression pathway
G1/S-Specific Transcription pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
E2F mediated regulation of DNA replication pathway
Generic Transcription Pathway pathway
Signal Transduction pathway
TGFBR1 KD Mutants in Cancer pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
Signaling by TGF-beta Receptor Complex pathway
Loss of Function of SMAD2/3 in Cancer pathway
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
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| KEGG |
TGF-beta signaling pathway pathway
Cell cycle pathway
TGF-beta signaling pathway pathway
Cell cycle pathway
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| INOH | |||||||||||||||||
| PID NCI |
Regulation of retinoblastoma protein
Direct p53 effectors
E2F transcription factor network
Regulation of nuclear SMAD2/3 signaling
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| Cross-References | |||||||||||||||||
| SwissProt | |||||||||||||||||
| TrEMBL | |||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||
| Entrez Gene | |||||||||||||||||
| UniGene | Bt.3383 | ||||||||||||||||
| RefSeq | NM_001076029 | ||||||||||||||||
| HUGO | |||||||||||||||||
| OMIM | |||||||||||||||||
| CCDS | |||||||||||||||||
| HPRD | |||||||||||||||||
| IMGT | |||||||||||||||||
| EMBL | |||||||||||||||||
| GenPept | |||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||