Version 5.4
Mus musculus Gene: Cdc25c
Summary
InnateDB Gene IDBG-135847.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdc25c
Gene Name cell division cycle 25C
Synonyms Cdc25
Species Mus musculus
Ensembl Gene ENSMUSG00000044201
Encoded Proteins
IDBP-135849
cell division cycle 25 homolog C (S. pombe)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158402:
This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:34732997-34751533
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000060710 ENSMUSP00000055427
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0050699 WW domain binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000087 mitotic M phase
GO:0006470 protein dephosphorylation
GO:0007067 mitotic nuclear division
GO:0007283 spermatogenesis
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000158402
View Gene Order
ENSBTAG00000005293
Not yet available
Pathways
NETPATH
REACTOME
REACT_240530
G2/M Transition pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_251223
G2/M DNA damage checkpoint pathway
REACT_188804
Cell Cycle pathway
REACT_256025
Cell Cycle Checkpoints pathway
REACT_235397
G2/M Checkpoints pathway
REACT_246508
Mitotic G2-G2/M phases pathway
REACT_206803
Cyclin A/B1 associated events during G2/M transition pathway
REACT_232236
Activation of ATR in response to replication stress pathway
REACT_209377
Cyclin B2 mediated events pathway
REACT_239497
Polo-like kinase mediated events pathway
REACT_236786
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex pathway
KEGG
mmu04110
Cell cycle pathway
mmu04914
Progesterone-mediated oocyte maturation pathway
mmu04114
Oocyte meiosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_6769
Activation of ATR in response to replication stress pathway
REACT_407
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex pathway
REACT_897
G2/M DNA damage checkpoint pathway
REACT_1006
Polo-like kinase mediated events pathway
REACT_1857
Cyclin A/B1 associated events during G2/M transition pathway
REACT_2101
Cyclin B2 mediated events pathway
REACT_828
G2/M Checkpoints pathway
REACT_115566
Cell Cycle pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_1538
Cell Cycle Checkpoints pathway
REACT_223914
G2/M Transition pathway
REACT_224007
Cyclin A/B1 associated events during G2/M transition pathway
REACT_217358
G2/M DNA damage checkpoint pathway
REACT_219578
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex pathway
REACT_215505
Cell Cycle, Mitotic pathway
REACT_217933
Mitotic G2-G2/M phases pathway
REACT_214934
Cell Cycle pathway
REACT_215433
Cyclin B2 mediated events pathway
REACT_206537
G2/M Checkpoints pathway
REACT_227740
Activation of ATR in response to replication stress pathway
REACT_220261
Polo-like kinase mediated events pathway
REACT_224819
Cell Cycle Checkpoints pathway
KEGG
hsa04110
Cell cycle pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04114
Oocyte meiosis pathway
INOH
PID NCI
plk3_pathway
PLK3 signaling events
atm_pathway
ATM pathway
atr_pathway
ATR signaling pathway
plk1_pathway
PLK1 signaling events
Cross-References
SwissProt P48967
TrEMBL Q3UR74
UniProt Splice Variant
Entrez Gene 12532
UniGene Mm.447470
RefSeq NM_009860 XM_006525550
OMIM
CCDS CCDS37759
HPRD
IMGT
MGI ID MGI:88350
MGI Symbol Cdc25c
EMBL AK141737 BC004669 CH466557 L16926 U15562
GenPept AAA37409 AAA74912 AAH04669 BAE24814 EDK97111
RNA Seq Atlas 12532

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca