Version 5.4
Mus musculus Gene: Skil
Summary
InnateDB Gene IDBG-136318.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Skil
Gene Name SKI-like
Synonyms Skir; sno; SnoN
Species Mus musculus
Ensembl Gene ENSMUSG00000027660
Encoded Proteins
IDBP-136320
SKI-like
IDBP-401611
SKI-like
IDBP-401610
SKI-like
IDBP-401609
SKI-like
IDBP-532643
SKI-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a small family of proteins that play a key role in the response of cells to extracellular growth signals. The encoded protein regulates members of the transforming growth factor beta signaling pathway. It is highly expressed in certain cancer cells, where it may have both tumor-suppressing and tumor-promoting roles. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:31095058-31122577
Strand Forward strand
Band A3
Transcripts
ENSMUST00000029194 ENSMUSP00000029194
ENSMUST00000118470 ENSMUSP00000113256
ENSMUST00000117728 ENSMUSP00000113054
ENSMUST00000118204 ENSMUSP00000112413
ENSMUST00000144756
ENSMUST00000123532 ENSMUSP00000123522
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 85 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 85 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0032403 protein complex binding
GO:0046332 SMAD binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001825 blastocyst formation
GO:0002260 lymphocyte homeostasis
GO:0007050 cell cycle arrest
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007283 spermatogenesis
GO:0007519 skeletal muscle tissue development
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0034097 response to cytokine
GO:0045596 negative regulation of cell differentiation
GO:0046677 response to antibiotic
GO:0050772 positive regulation of axonogenesis
GO:0070207 protein homotrimerization
GO:0070208 protein heterotrimerization
GO:0070306 lens fiber cell differentiation
GO:0070848 response to growth factor
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016605 PML body
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000136603
View Gene Order
ENSBTAG00000004154
Not yet available
Pathways
NETPATH
REACTOME
REACT_217958
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_189085
Disease pathway
REACT_215068
Loss of Function of SMAD4 in Cancer pathway
REACT_213336
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_224217
TGFBR1 LBD Mutants in Cancer pathway
REACT_220566
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
REACT_204241
Loss of Function of TGFBR2 in Cancer pathway
REACT_216792
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_224787
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_233572
Gene Expression pathway
REACT_223317
Loss of Function of TGFBR1 in Cancer pathway
REACT_209370
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_202264
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_206529
Generic Transcription Pathway pathway
REACT_188257
Signal Transduction pathway
REACT_224802
TGFBR1 KD Mutants in Cancer pathway
REACT_212101
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_225428
Signaling by TGF-beta Receptor Complex pathway
REACT_226256
Loss of Function of SMAD2/3 in Cancer pathway
KEGG
INOH
INOH website
TGF-beta signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_121111
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_121061
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
KEGG
INOH
INOH website
TGF-beta signaling pathway
PID NCI
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
Cross-References
SwissProt Q60665
TrEMBL D3YYG2 Q3TQJ9 Q78E91
UniProt Splice Variant
Entrez Gene 20482
UniGene Mm.15406 Mm.468161
RefSeq NM_011386 XM_006535427 NM_001039090 NM_001271772
OMIM
CCDS CCDS38408 CCDS50886 CCDS71230
HPRD
IMGT
MGI ID MGI:106203
MGI Symbol Skil
EMBL AC117590 AK163526 BC049934 U10530 U10531 U10532 U14655
GenPept AAB50266 AAB50267 AAB50584 AAB65849 AAH49934 BAE37383
RNA Seq Atlas 20482

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca