Version 5.4
Mus musculus Gene: Ifrd1
Summary
InnateDB Gene IDBG-136330.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ifrd1
Gene Name interferon-related developmental regulator 1
Synonyms Ifnl; PC4; Tis7
Species Mus musculus
Ensembl Gene ENSMUSG00000001627
Encoded Proteins
IDBP-136332
interferon-related developmental regulator 1
IDBP-624968
interferon-related developmental regulator 1
IDBP-624971
interferon-related developmental regulator 1
IDBP-624973
interferon-related developmental regulator 1
IDBP-624974
interferon-related developmental regulator 1
IDBP-624976
interferon-related developmental regulator 1
IDBP-624979
interferon-related developmental regulator 1
IDBP-624980
interferon-related developmental regulator 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 26055519
[Homo sapiens] Human papillomaviruses impair the acetylation of NFκB/RelA K310 in keratinocytes by augmenting the expression of interferon-related developmental regulator 1 (IFRD1) in an EGFR-dependent manner.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000006652:
This gene is an immediate early gene that encodes a protein related to interferon-gamma. This protein may function as a transcriptional co-activator/repressor that controls the growth and differentiation of specific cell types during embryonic development and tissue regeneration. Mutations in this gene are associated with sensory/motor neuropathy with ataxia. This gene may also be involved in modulating the pathogenesis of cystic fibrosis lung disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:40201567-40248504
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000001672 ENSMUSP00000001672
ENSMUST00000164047 ENSMUSP00000127553
ENSMUST00000170119
ENSMUST00000171530 ENSMUSP00000128635
ENSMUST00000169926 ENSMUSP00000127673
ENSMUST00000165027 ENSMUSP00000133028
ENSMUST00000169319 ENSMUSP00000130824
ENSMUST00000170752
ENSMUST00000164354 ENSMUSP00000130846
ENSMUST00000171553 ENSMUSP00000127954
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
Biological Process
GO:0007275 multicellular organismal development
GO:0007527 adult somatic muscle development
GO:0042692 muscle cell differentiation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000006652
View Gene Order
ENSBTAG00000010549
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 15982
UniGene Mm.168
RefSeq NM_013562
OMIM
CCDS CCDS25893
HPRD
IMGT
MGI ID MGI:1316717
MGI Symbol Ifrd1
EMBL
GenPept
RNA Seq Atlas 15982

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca